Avinash Kumar

Dasatinib (DAS) is a tyrosine kinase inhibitor used in the treatment of chronic myeloid leukemia (CML) and erythromycin (ERY) is macrolide antibiotic used to treat a range of inflammatory conditions are often co-administered in clinical practice. The simultaneous estimation of DAS and ERY helps in understanding the pharmacokinetics and drug–drug interactions. In this respect, we presented novel, sensitive, and validated bio-analytical LC-ESI-MS/MS method for simultaneous estimation of DAS and ERY in CD-1 mice plasma. The LLOQ was 2.0 ng/mL with an S/N ratio of 15. This validated method was used to study the PK of DAS and ERY in mice following intravenous and oral administration. The DAS was administered at 5 mg/kg via both oral and intraveneous route, whereas ERY was administered at 50 mg/kg orally and 5 mg/kg intraveneousaly. Following intravenous dosing, DAS showed high clearance and distribution, while ERY exhibited high clearance and distribution. The oral bioavailability was 64% for DAS and 21% for ERY. When co-administered orally at 5 mg/kg for DAS and 50 mg/kg of ERY, the

Sachin suffered a bullet injury to his right leg and is undergoing treatment at the government-run Jawaharlal Nehru Medical College and Hospital (JLNMCH), Bhagalpur.

Neeraj Kumar Sinha and Prashant Kishor filed nominations for the July 30 Bankipur byelection, ensuring a triangular contest amid political tensions.

Here's India's predicted playing XI for the 1st ODI of the three-match series against England, set to be played at Edgbaston, Birmingham on Tuesday.

Jos Buttler, who made his ODI debut against Pakistan in Dubai on February 21, 2012, joins former World Cup-winning captain Eoin Morgan in an elite list of England cricket players.

» » Product Strategy & Consulting Imagine you spent months and thousands of riyals building a new software product for your business in Saudi Arabia.

Ravish was named as the main accused for the abduction of Bunty Kumar, who was kidnapped near Patna Junction on the intervening night of July 5 and 6 after he opposed an alleged sex racket

Victim Bunty Kumar was abducted near Patna Junction under Kotwali police station late on July 5, with his body being recovered on July 11 from a field in Athmalgola area. The case has created a lot of uproar in the capital.

Agroforestry has emerged as an important land-use strategy for addressing global challenges such as food security, environmental degradation, and livelihood sustainability. With increasing population pressure and declining agricultural and forest lands, nature-based solutions like agroforestry offer sustainable pathways to enhance food production, maintain soil fertility, and generate diversified income opportunities for rural communities. By integrating trees with crops and livestock, agroforestry systems mimic natural ecosystems and provide multiple ecological benefits, including improved soil health, biodiversity conservation, and climate resilience. In addition to ecological advantages, agroforestry contributes to poverty alleviation and supports several Sustainable Development Goals (SDGs). Recognizing its potential, India became the first country to adopt the National Agroforestry Policy in 2014, aimed at promoting agroforestry for employment generation, industrial utilization, and value addition. Furthermore, the GROW report by NITI Aayog estimates that approximately 55.76 million hectares of wastelands in India could be restored through agroforestry interventions. This review highlights the role of agroforestry in addressing food security, environmental restoration, and rural economic development, while also examining the progress of government policies supporting agroforestry initiatives. Strengthening policy support and investment in agroforestry can enhance sustainability, improve rural livelihoods, and promote resilient landscape restoration, positioning agroforestry as a key strategy for sustainable development.

Veteran opener Rohit Sharma is on the verge of bringing the curtain down on his India career, with the third and final ODI against England at Lord's potentially set to be his last appearance in the format. Reports suggest that the Ajit Agarkar-led selection committee is planning to move on from Rohit to groom a younger opener for the 2027 ODI World Cup.