Miami Beach, United States (Local)
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Alex Miranda's coverage primarily focuses on local entertainment news and events in the Miami area, with an emphasis on film, restaurants, and celebrity appearances. Given this focus, he may be interested in receiving pitches related to upcoming local events, new restaurant openings or menu launches, as well as exclusive interviews with celebrities visiting or working in the Miami area.
Since Alex covers a wide range of entertainment topics such as films and TV shows along with house & home-related content like restaurants and waterfront venues, consider pitching stories that present unique angles or exclusive access to these subjects within the local Miami context. This could include behind-the-scenes looks at film productions in the area or spotlighting distinctive aspects of South Florida's dining scene.
When reaching out to Alex Miranda for potential coverage opportunities ensure that your pitch aligns with his focus on promoting local events and providing expert commentary relevant to the Miami audience.
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By: Alex Miranda
Share The Seminole Hard Rock Hollywood Hotel is kicking off Pride Month one day early this Sunday with Hard Rock Drag Brunch, which is all for a great cause.
By: Ki-Jana King, Alex Miranda
Share In a city known for food fusion — one North Miami spot is mixing Haitian culture with a slice of comfort.
By: Matthew Auerbach, Alex Miranda
Share It's not hard to go to a restaurant for dinner. People do it all the time. If you could go around the globe without getting up from your table, that'd be cool!
By: Kathy Paz, Alex Miranda
Share There's something about black-and-white media that hits differently. It's cool, has a vintage feel and it's usually a little mysterious.
By: Alex Miranda
Share We are facing a testosterone overload. We have Alex Miranda covering the opening of “Masters of the Universe.” The 1980s are back, now
By: Alex Miranda
Share A horror movie isn't truly a classic until “Scary Movie” takes a stab at it. Deco's own scream queen, Alex Miranda, sat down with some of the stars of the killer franchise.
By: Alex Miranda
Share The hottest Pride party in town this weekend is floating. Fort Lauderdale's FLoatarama is the biggest Pride-on-the-water event of its
By: Collins K. Cheruiyot, Sarah Y. Kim, Juan Dubrot, Sarah K. Lane-Reticker, Alex Miranda, Ashwin V. Kammula, Jonathan J. Perera, Cun Lan Chuong, Rachel A. Fetterman, Nelson H. Knudsen, Aiping Jiang, Cong Fu, Seth Anderson, Audrey J. Muscato, Omar I. Avila
Tumor cells respond and adapt to environmental stresses that facilitate growth in hostile environments, including cytokine-mediated inflammation elicited by antitumor immunity and enhanced by immune checkpoint blockade (ICB). However, cytokine responses also induce transcriptional and cell-state changes that may predispose tumor cells to new vulnerabilities, which remain poorly explored. Here we performed in vitro genome-scale CRISPR loss-of-function screens in eight cancer models exposed to interferon-γ (IFNγ), interferon-β or tumor necrosis factor to map inflammation-induced genetic vulnerabilities. We identified members of the glycosylphosphatidylinositol (GPI) transamidase complex and the lipid phosphatase FITM2 as interferon-specific cancer dependencies. Tumor-specific deletion of GPI transamidase subunits or FITM2 markedly enhanced response to ICB in vivo. By integrating functional genomics, metabolomics and pharmacologic perturbation of downstream stress pathways, we found that loss of FITM2 predisposed cancer cells to IFNγ-driven endoplasmic reticulum and oxidative stress, culminating in paraptosis-like cell death. Collectively, these findings identify tumor-intrinsic dependencies governing responses to inflammatory cytokines.
By: Alex Miranda
Share Stop that train. A new RuPaul comedy crashes into theaters this weekend.
By: Alex Miranda, Litzy Grijalba
Share We never had an excuse to play Hooky. Well, we're going to give you one anyway. You'll thank us later.
