Anna Francis

This year Grand Union celebrates fifteen years of artist-led activity in Digbeth, the rapidly developing district close to Birmingham city centre. In that time the gallery and artists' studio complex has secured a reputation as a place to experience the best in experimental and socially relevant arts programming. Their events and exhibitions have become a prominent and important facet of the arts ecosystem in the region, and the organisation has demonstrated how the right timing, careful consideration of place and its complex histories, alongside a significant amount of graft, can secure space within major city-wide development; not just for the activities of artists, but for the nurturing of a whole series of meaningful relationships and entanglements.

As Liam Lawson rebuilds his F1 career with Racing Bulls, we take a look at other examples of drivers turning disappointment into success...

Sharon Donovan first studied play therapy during her graduate work in counselor education in the University of South Carolina College of Education almost 20 years ago.

Hyperammonaemia is a potentially reversible cause of encephalopathy that can mimic focal neurological syndromes. A man in his 60s presented with light-headedness, vomiting and abdominal pain. He developed acute aphasia and right-sided weakness within 24 hours, and although serial CT brain imaging and CT angiography were normal, conscious level deteriorated rapidly, such that he required intubation and mechanical ventilation. MRI brain demonstrated symmetrical basal ganglia T1 hyperintensity. Metabolic investigation identified hyperammonaemia (147 µmol/L). He was treated with lactulose, rifaximin and continuous veno-venous haemofiltration with biochemical and neurological improvement and resolution of neurological deficits. In the absence of overt liver failure, small bowel bacterial overgrowth was considered the most likely cause although potential additional contributory factors were also identified. This case highlights the need to measure ammonia early in otherwise unexplained encephalopathy, even when liver function tests are normal.