Anthony Anderson

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NAPPANEE — Ava Sanders says the days on which she pitches, to go alongside her everyday role in the Elkhart softball batting order, are the games she likes best, in part because “it makes the games go a bit faster.”

NAPPANEE — Several instances of possible rain delays made it feel like Senior Night at NorthWood might stretch into Postgraduate Night.

Cedric the Entertainer and Anthony Anderson say these smoky Memphis-style ribs are guaranteed to be a crowd-pleaser

This California-inspired slaw, with lime and charred veggies, comes from a 2026 cookbook by Anthony Anderson and Cedric the Entertainer

NAPPANEE — NorthWood hosted four high school baseball games Saturday at its Field of Dreams complex, and halfway through it, paused to salute a pair of men who surely would've loved all that action, if not so much the results.

GOSHEN — The arm and the bat of Goshen senior Bray Hoag and the daring dashing of Concord senior Jordan Flores helped spark the RedHawks and Minutemen into Monday’s Goshen

BENTON — Right after NorthWood secured a Class 3A baseball sectional title three-peat Monday night with a 6-2 win over host Fairfield, coach Zach Benko huddled his collectively young Panthers

Purpose and methodsRefractory and/or resistant herpes simplex virus (R/R HSV) mucocutaneous infections are an emerging challenge in immunocompromised hosts. A single-center retrospective study of R/R HSV mucocutaneous infections in allogeneic hematopoietic cell transplantation (HCT) was conducted on cases identified between 2023 and 2025. Cases were categorized using the 2025 consensus definitions. We collected data on the clinical presentation, risk factors, and outcomes and investigated the genetic mechanisms of resistance.ResultsFive cases of R/R HSV following HCT were identified. Four patients had documented UL23 gene resistance mutations. The median time from HCT to R/R HSV was 642 days. All the patients were recipients of unrelated or mismatched donors. Three (60%) had relapsed hematological disease. The CD4 lymphopenia (<200 cells/µL) and hypogammaglobulinemia (IgG <600 mg/dL) were present in three patients (60%) and four patients (80%), respectively. The median cumulative exposure to (val)acyclovir prior to R/R HSV was 30 months (range: 18 to 51 months). Foscarnet was used in all patients as initial therapy. Viremia was present in four (80%) cases, with clearance of viremia in response to antiviral therapy in only two. Acute renal failure and electrolyte disturbances related to antiviral therapy occurred in two patients (40%) and four patients (80%), respectively. Despite protracted courses of antivirals (lasting up to nine weeks), no patient achieved complete healing. Three-month mortality was 80% (n=4), although none of the deaths were directly attributed to the HSV infection.ConclusionRefractory and/or resistant herpes simplex virus is a rare but serious complication of HCT. Current antivirals for R/R HSV infections have suboptimal efficacy and safety profiles.

NAPPANEE — Fittingly powered in part by back-to-back Bradys — Weaver and Blackford — at the back of its batting order, NorthWood baseball is a first-time back-to-back regional champion.