Arkadi Mazin

GLP-1 receptor agonists may not affect muscle mass any more than weight loss caused by caloric restriction, and this appears to be true for strength as well.

Scientists have found a way to drastically ramp up mouse immune responses to cancer along with flu and COVID-19 [1]. How to wake up the immune system Modern cancer immunotherapies only work for a minority of patients. The reason, broadly, is that many tumors are immunologically “cold”: they do not trigger, and/or actively suppress, the

Scientists have devised a CRISPR-based tool that can kill cells carrying a specific strand of RNA. The tested targets include cancerous and virus-infected cells [1]. Targeted assassination of cells CRISPR-based systems work by cutting or changing DNA at a particular spot, an ability that can be used to fix dangerous mutations, such as in the

Scientists have uncovered an unexpected function of the tau protein, which is mostly known for its role in Alzheimer's: helping encode long-term memory.

The longevity field remains small and starved for resources, especially the subfield devoted to the fundamental biology of aging, despite near-universal agreement that solving aging requires understanding it first. With VCs looking for clinical successes and state funding drying up for many projects, some enthusiasts are turning to a nonprofit model. That path is anything

According to a new study, a special protein disposal system, currently found only in neurons, is linked to central hallmarks of Alzheimer’s disease.

In a new study, muscle-targeted viral-vector-based delivery of the protein FGF21 significantly increased median lifespan in male mice and improved many healthspan markers [1]. Control your energy Metabolic dysregulation is a core cause of aging [2]. As animals (and people) age, they tend to gain fat, develop insulin resistance, and run their cellular energy systems

A new study predicts whether existing drugs can extend human lifespan by using a network approach that detects longevity signals in protein interactions.

Restricting food access to an 8-hour window increased median lifespan in male mice by 12%. However, that might be due to voluntary caloric restriction induced by the regimen [1]. You are when you eat Time-restricted eating (TRE), also known as intermittent fasting, has become a popular health practice due to a slew of animal studies

Scientists have linked disrupted Ca²⁺ homeostasis to aging in both progeroid and naturally aging mice. Rescuing it significantly increased their lifespan.