Arun Nair

The Enforcement Directorate's (ED) preliminary investigation has found that about Rs 160 crore was transferred from the TMC's bank accounts to Carewell Aviation India Pvt. Ltd. and its related entity between April 2023 and June 2026, news agency PTI reported.

With the impressive win, India extended its impressive red-ball record to seven victories, three draws and one defeat in their last 11 Women's Tests, while also maintaining their unbeaten record in Women's Tests in England.

Despite a 29% correction in value over the year, Gurugram-based DLF retained its title as India’s most valuable real estate company with a value of INR 1.47 lakh crore.

PM Modi announced an ex gratia of Rs 2 lakh from the Prime Minister's National Relief Fund (PMNRF) to the relatives of the dead, while Rs 50,000 would be provided to every injured person.

A Gen Z movement that started as satire has quickly become a mass movement, with thousands of Cockroach Janata Party protesters braving a police

The injured were taken to a medical facility at the airport for precautionary examination and care by Air India's airport team and medical personnel, the airline said.

The Tamilaga Vettri Kazhagam-led government in Tamil Nadu presents its 2026-27 Budget focusing on transforming the state into a 1.5 trillion-dollar economy by 2031, with major investments in education, fiscal reform, and welfare schemes.

Li-Fraumeni Syndrome (LFS) is a rare autosomal dominant hereditary cancer predisposition syndrome caused by germline mutations in the TP53 tumor suppressor gene, conferring a markedly increased lifetime risk of multiple early-onset malignancies. Pediatric patients are particularly susceptible to developing soft tissue sarcomas, osteosarcomas, adrenocortical carcinomas, central nervous system tumors, and hematologic malignancies, necessitating early recognition and lifelong surveillance. Over the past decade, substantial advances in the understanding of TP53 biology have deepened insight into the molecular mechanisms underlying tumor development and informed the evolution of comprehensive surveillance strategies. This literature review summarizes the current understanding of the molecular pathogenesis of LFS, reviews the pediatric cancer spectrum, and compares contemporary surveillance recommendations, including the Toronto protocol, European Reference Network (ERN) GENTURIS guidelines, and recent American Association for Cancer Research (AACR) recommendations. We further discuss current clinical management, challenges associated with lifelong surveillance, and emerging therapeutic approaches, including mutant p53 reactivation, synthetic lethality strategies, and pharmacologic cancer prevention with agents such as metformin. Although no targeted therapy has been approved specifically for individuals with LFS, advances in precision medicine and ongoing clinical trials continue to expand the potential for preventive and therapeutic options. Continued international collaboration, prospective clinical research, and integration of molecular discoveries into clinical practice will be essential to optimize surveillance protocols, develop effective targeted interventions, and improve long-term outcomes for children and families affected by Li-Fraumeni Syndrome.

Sashidhar Jagdishan, managing director and chief executive of HDFC Bank , on Saturday decided not to seek reappointment after his current term ends on October 26.

In a big win for the Cockroach Janta Party (CJP), the Supreme Court quashed all police cases registered against protesters during demonstrations over the NEET paper leak.