By: Benjamin P. Levy, Siddhartha Devarakonda, D. Ross Camidge, Julia K. Rotow, Gilberto Lopes
Dr. Rotow discusses limitations of traditional CTCAE toxicity grading for capturing patient experiences with EGFR-targeted therapies. Although useful for discrete, measurable, and life-threatening toxicities, CTCAE poorly captures lower-grade effects like skin rash or fatigue that significantly impact quality of life over extended treatment periods.







