Bhaskar Mukherjee

India News: Communal clashes broke out in Nuh on Monday afternoon after a religious procession passing through the district came under attack, leaving two home gu

Communal clashes broke out at Nuh chowk on Monday afternoon when around 80 vehicles and bikes carrying participants of the Brij Mandal Jalabhishek Ya

Hours into communal violence that broke out in Nuh, mobs went on the rampage for over an hour at Sohna Chowk in the city on Monday, breaking through a

The district administration denied permission to a mahapanchayat planned by the Vishwa Hindu Parishad (VHP) in Manesar on Wednesday. The temple where

India News: Continuing its drive against “illegal constructions” for the fourth straight day, the Nuh administration on Sunday brought down a three-storey restaur

BackgroundPatients with major depressive disorder have varying response rates to treatment. Multiple factors such as non-adherence, comorbidity, chronic stressors, and biological factors may be responsible for this variation. Inflammatory (pro and anti) markers have been well studied as a cause for depression, predisposing factors, and a consequence of depression. Among these, interleukins (ILs), interferons, C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-α) have been studied repeatedly. We conducted a pilot study to assess the levels of these inflammatory markers in patients with major depressive disorder. The specific objectives of this study were to compare and correlate changes in pro- and anti-inflammatory markers throughout different phases of depression, including pretreatment and posttreatment periods, and to evaluate the pattern of pro- and anti-inflammatory markers in patients who experienced remission or showed a positive response to treatment.MethodologyThis was a prospective, clinic-based, cohort study done for a period of one and a half years. Patients aged 18-65 years with depressive disorder per the International Classification of Diseases Tenth Edition and who scored more than 7 on the Hamilton Depression Rating Scale were included in this study. A total of 81 patients were recruited who were followed up till eight weeks after inclusion. A total of 31 patients completed the eight weeks of follow-up. Levels of IL-10 and TNF-α were assessed at baseline, two weeks, four weeks, and eight weeks of follow-up.ResultsThis study tried to compare the levels of pro- and anti-inflammatory markers across pretreatment and various posttreatment phases of depression. Results showed that the levels of pro-inflammatory cytokine TNF-α increased from baseline till eight weeks of follow-up, and levels of IL-10 decreased from baseline till eight weeks of follow-up. However, these changes were not statistically significant.ConclusionsThis study supports the hypothesis that inflammatory markers can be trait markers of depression rather than the consequence or result.

Residents of Nuh stepped out cautiously on Thursday as the curfew was relaxed for eight hours for the first time since the July 31 communal clashes sa

A team of the Haryana Police was fired at early on Thursday when they went to arrest two men allegedly involved in the July 31 attack on a religious

In conversation with Dr. Bhaskar Mukherjee, Consultant Psychiatrist, Special Interest Molecular Psychiatry, regarding male hormonal disturbances

Periodically driven quantum systems host exotic phenomena that often do not have any analog in undriven systems. Floquet prethermalization and dynamical freezing of certain observables, via the emergence of conservation laws, are realized by controlling the drive frequency. Recent experimental developments in synthetic quantum matter, such as superconducting qubits and cold atoms, have opened avenues for implementing local Floquet engineering which can achieve spatially modulated quantum control of states. Here, we uncover the novel memory effects of local periodic driving in a nonintegrable spin-half staggered Heisenberg chain. For a boundary-driven protocol at the dynamical freezing frequency, we show the formation of an approximate strong zero mode, a prethermal quasilocal operator, due to the emergence of a discrete global symmetry. This is captured by constructing an accurate effective Floquet Hamiltonian using a higher-order partially resummed Floquet-Magnus expansion. The lifetime of the boundary spin can be exponentially enhanced by enlarging the set of suitably chosen driven sites. We demonstrate that in the asymptotic limit, achieved by increasing the number of driven sites, a strong zero mode emerges, where the lifetime of the boundary spin grows exponentially with system size. The nonlocal processes in the Floquet Hamiltonian play a pivotal role in the total freezing of the boundary spin in the thermodynamic limit. The novel dynamics of the boundary spin is accompanied by a rich structure of entanglement in the Floquet eigenstates where specific bipartitions yield an area-law scaling while the entanglement for random bipartitions scales as a volume-law. Our work addresses the long-standing question of the existence of a strong zero mode in a nonintegrable model and elucidates the complex nature of thermalization in locally driven systems.