Jiao Tong

A: the number of age groups; a : the age-specific rate in i th the age group. w : the number of people in the corresponding i th age group among the standard population.

where i represents the model gene, Coef denotes the regression coefficient, and ExpGene indicates the corresponding gene expression level.

Abstract The aim of the study was to propose a framework for practical and fundamental model functional designs for the modernization of

Abstract Music possesses a remarkable capacity to evoke a broad spectrum of subjective responses and promote healing in humans, with rhythm playing a crucial role among its various elements.

Yaqi Qiu ∙ Guangxin Luan ∙ Yiwen Liu ∙ … ∙ Cuixia Yang ∙ Yan Du [email protected] ∙ Feng

Zhiyang Chen Xiaoman Zhu Michael Mingze Lu Qingjian Ou Xueying Wang Zhenzhen Zhao Qi Shen

The World Alzheimer Report 2024 estimates 55 million people worldwide currently have dementia, a number projected to reach 139 million by

Zinc-iodine batteries (ZIBs) are promising candidates for safe and sustainable energy storage but are hindered by polyiodide shuttling, leading to rapid capacity decay and limited cyclability.

This study uses two-sample MR analysis with GWAS summary statistics to evaluate the causal relationship between metabolic syndrome and low back pain. A two-sample Mendelian randomization analysis used GWAS summary statistics for low back pain from the FinnGen database and metabolic syndrome data, including waist circumference, hypertension, fasting blood glucose, HDL cholesterol, and triglyceride levels. Various methods like inverse variance weighted, MR-Egger, weighted median, and mode assessed the causal relationship, with sensitivity analyses addressing heterogeneity and pleiotropy. Our analysis found a statistically significant causal association between essential hypertension (OR  2.38, 95% CI 1.42–3.96; Padj = 0.002), metabolic syndrome (OR  1.05, 95% CI 1.01–1.10; Padj = 0.023) and waist circumference (OR   49, 95% CI 1.32–1.68; Padj < 0.001) and low back pain (OR  1.41, 95% CI 1.30–1.53, Padj < 0.001). In contrast, fasting blood glucose (FBG), HDL cholesterol, and triglycerides showed no significant associations with low back pain across all MR methods. The results of sensitivity analyses indicated that the heterogeneity and pleiotropy were unlikely to disturb the causal estimate. Our study indicates that increased essential hypertension, metabolic syndrome and waist circumference is causally associated with a higher risk of low back pain. Interventions targeting metabolic syndrome components, particularly blood pressure control and weight management, could help reduce the risk of low back pain. Further research is needed to explore the underlying biological pathways linking these metabolic factors to low back pain.

Abstract Objective To compare the clinical efficacy of the separate vertical wiring (SVW) technique and conventional tension band