Lei Wu

The escalating global energy demand has spurred intensive research into alternative energy technologies, among which proton-exchange membrane fuel cells (PEMFCs) stand out for their high efficiency and environmental benignity. However, conventional proton conductors like Nafion® face critical limitations, in

Author summary Type I interferon (IFN-I) restricts viral replication, and cGAS activates its production upon detecting viral DNA. Alpha-herpesviruses, such as pseudorabies virus (PRV) and herpes simplex virus type 1 (HSV-1), cause severe neurological and mucocutaneous problems in their hosts. However, the unified mechanisms behind immune evasion in alpha-herpesviruses remain largely unknown, hindering the development of broad-spectrum vaccines and antiviral drugs. Here, we demonstrate that overlapping peptides from alpha-herpesvirus-encoded immediate early US1 proteins directly bind to and inhibit cGAS activation. Deletion of these peptides in US1 proteins resulted in enhanced cGAS-mediated IFN-β production. Importantly, PRV-ΔUS1 or HSV-1-ΔUS1 exhibited increased IFN-β secretion and reduced viral loads in vivo. This potential mechanism reveals a unique strategy for developing broad-spectrum antiviral drugs targeting alpha-herpesviruses.

Suspension polymerization may play a crucial role in synthesizing multiblock copolymers for functional architectures. In this study, water (H2O) was employed as the continuous dispersion medium, hydr...

Over the past few decades, the discovery of novel microbial processes, biochemical reactions, and previously uncharacterized microorganisms has significantly enhanced our understanding of nitrogen (N) cycling across terrestrial and aquatic ecosystems, including engineered environments such as wastewater treatment systems.

The axial coordination of iron phthalocyanine to carbon nanotubes through a pyridine ligand boosts the supply of active hydrogen (H*) from water dissociation and accelerates H*-mediated nitrate reduc...

The aim of the present study was to investigate the effects of different dietary protein levels on the carcass traits, meat quality characteristics, and nutrient composition of slow-growing ducks.

This study systematically evaluated the dynamic habitat suitability of Portunus trituberculatus in the East China Sea and the Yellow Sea region (referred to herein as the East Yellow Sea region for brevity) under climate change impacts by integrating a species distribution model (Biomod2) with multi-source environmental data. Through the construction and evaluation of an ensemble model combining 10 algorithms, using the Area Under the Curve (AUC) and True Skill Statistic (TSS) for validation, we identified seabed temperature, seabed salinity, and chlorophyll as key environmental factors. Results showed that current high-suitability areas are concentrated in coastal Jiangsu, the Yangtze River estuary, and Zhoushan Archipelago waters, which overlap significantly with fishing hotspots. Under future climate scenarios, the species’ suitable habitat distribution is projected to shift significantly poleward: In the SSP5-8.5 scenario 2100, low/medium suitability areas increased by 38.2% and 88.2% respectively, while high-suitability areas decreased by 36.5%, with core spawning grounds (e.g., Zhoushan Archipelago waters) showing reduced suitability indices. The Bohai Sea’s summer water temperature unsuitability for Portunus trituberculatus migration creates an “ecological bottleneck” for northward expansion. The study proposes strengthening habitat management in Jiangsu coastal areas and integrating dynamic habitat prediction into fisheries policies to address climate-induced resource redistribution and ecosystem service changes. Our findings underscore the urgency of incorporating climate-driven habitat shifts into adaptive marine spatial planning and fisheries management frameworks.

Microneedle array platforms for drug delivery and biomarker sensing: From skin mechanics guided design to scalable manufacture for clinical utility