Paddy Murphy

We've got four shouts for Saturday's early Craven Cottage KO. Saturday's early kickoff sees Marco Silva's Fulham hosting Unai Emery's Aston Villa at Craven Cottage.

Football Tips: Our tipster's preview & 9/1 Acca for Saturday's Serie A, La Liga & Ligue 1 action, 25th April 2026.

Background Coronary microvascular dysfunction (CMD) is common among patients with angina with non-obstructive coronary artery disease (ANOCA) and leads to poorer clinical outcomes. Exercise stress testing (EST) was shown to have a high specificity for detecting CMD. However, the relationship between diagnosing CMD using different invasive physiological parameters and thresholds and the association between EST findings and the endotype of CMD remains unknown.Methods This multicentre, prospective cohort study enrolled 117 patients with ANOCA who underwent EST prior to invasive coronary angiography with functional assessment to measure coronary flow reserve (CFR), the index of microvascular resistance (IMR) and microvascular resistance reserve (MRR)=(CFR/FFR)×(Pa rest/Pa hyper). CMD was classified using multiple criteria, including MRR <3.0, CFR <2.5 and CFR <2.0 or IMR ≥25. Diagnostic sensitivity and specificity and the accuracy of EST findings (exercise-induced chest discomfort, ischaemic ECG changes and exercise intolerance) for diagnosing CMD were assessed.Results The prevalence of CMD was similar under all three definitions. However, structural CMD was more common using MRR <3.0. Ischaemic ECG changes during EST showed an excellent diagnostic accuracy of 86.3% (78.7–92.0%) for detecting CMD, with a sensitivity and specificity of 86.2% (68.3–96.1%) and 86.4% (77.4–92.8%), respectively. Exercise-induced chest discomfort also had a good diagnostic accuracy of 76.1% (95% CI 67.3% to 83.5%); however, it offered no additional value when added to ischaemic ECG changes. EST preferentially identified structural CMD, while functional CMD was more frequently missed.Conclusions Ischaemic ECG changes during EST performed immediately before invasive functional assessment demonstrated excellent diagnostic accuracy for identifying patients with CMD, particularly the structural endotype.Trial registration number [NCT05841485][1].Data are available upon reasonable request. Requests should be made to the corresponding author.[1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT05841485&atom=%2Fheartjnl%2F112%2F11%2F615.atom

It's goals all round… Salford hold a 2-1 lead heading into Friday night's second leg of their match with Grimsby and take that lead back to the Peninsula Stadium.

We've got five value as the Gunners push for the title. Arsenal can extend their superior points gap over Manchester City when they take on

Last week the Studebaker Theater in downtown Chicago hosted K-Pop ensemble AMPERS&ONE for their Born to Define Tour.

We've got five picks for Saturday's Wembley showdown. The sees Hull taking on Middlesbrough at Wembley. The Spygate shenanigans are done with, for now at least.

Six games, six tips, let's go… And so, that's that for another season of the . Arsenal are champions, Manchester City are not.

We've got four picks for Saturday's Budapest showdown. Can PSG make history in Budapest and become the 10th club to defend the European