Rajeev Kumar

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that affects nearly 3.41 million people globally, with 90% of the cases affecting women of childbearing age. SLE is a complex disease due to the interplay of various immunological pathways and mechanisms. This scoping review aims to highlight the latest research findings on the therapeutic mechanisms of action of EVs in SLE. Relevant research articles were identified using the PRISMA framework from databases such as PubMed/MEDLINE (National Library of Medicine), Scopus (Elsevier), and Web of Science: Core Collection (Clarivate Analytics) from July 2023 to October 2023. Eleven studies met the inclusion criteria and thus were included in this scoping review. The findings showed that EVs have therapeutic effects on ameliorating the disease progression of SLE. EVs can reduce the pro-inflammatory cytokines and increase the anti-inflammatory cytokines. Moreover, EVs can increase the levels of regulatory T cells, thus reducing inflammation. EVs also have the potential to regulate B cells to alleviate SLE and reduce its adverse effects. The scoping review has successfully analysed the therapeutic potential in ameliorating the disease progression of SLE. The review also includes prospects to improve the effects of EVs further to increase the therapeutic effects on SLE.

‘Stand committed to hold assembly polls immediately after general elections’

The spell he casts seems eternal. Gabriel Garcia Marquez walks tall over the literary landscape of Kerala as if it is a small stretch of Latin America where the man is revered as the God of literature. Even after a decade since his death, this great writer from Latin America, is still being celebrated by the literati here, as if he had arrived at the scene first with his redoubtable tour de force 'One Hundred Years of Solitude' which had redrawn the boundaries of literature with the mesmerizing 'magical realism', leaving the readers across the world spellbound.

Abstract Nitrogen (N) and phosphorus (P) are vital for crop growth. However, most agricultural systems have limited inherent ability to supply N and P to crops.

The collective wail of the fraternity sounds deafening and the cacophonous resonance of the message becomes a bit intimidating too. Initially, the dissent seemed spontaneous, but as one delves deep, the situation looks murky, unbecoming of a pristine art, leaving many people frustrated, disillusioned and disgruntled, with the entire classical music world divided into two.

Specimens of 316 L stainless steel were printed using laser powder bed fusion (LPBF), a popular metal additive manufacturing (AM) technique, with varying island sizes. Not many researchers have considered the impact of spatter while optimizing LPBF printing parameters. In this research, the influence of spatter was considered while also investigating the effect of varied island size on the microstructure, surface roughness, microhardness, and corrosion resistance of LPBF-316 L. No correlation was observed between surface roughness or microhardness and minor variations in island size. However, a correlation was drawn between varied island sizes and porosity in LPBF-316 L. The specimens associated with larger island sizes showed significantly enhanced corrosion resistance due to fewer manufacturing defects and reduced porosity, attributed to the minimal influence of the spatter. Based on analysis, the LPBF parameters were revised, which lead to superior corrosion resistance of LPBF-316 L, attributed to high density and reduced porosity.

Custom Duty | Judiciary

Mahe: Only for the second time in the history of elections in India, the polling process in an assembly segment will be fully officiated by women.

Biological neurons are electro-mechanical systems, where the generation and propagation of an action potential are coupled to the generation and transmission of an acoustic wave. Neuristors, such as VO

Before Rajmohan Unnithan wrested back Kasaragod seat in 2019, the last UDF candidate who had won from Kasaragod was Ramanna Rai, in the elections held in 1984. Only Suresh Kurup of CPM could sail past the sympathy wave which lashed across the country