Sean Brady is a reporter for Kamloops This Week, focusing on local news in Kamloops, British Columbia. With a keen interest in community events, cultural happenings, and municipal affairs, Sean covers a wide range of topics, from city council meetings to local theater productions.
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Kamloops, British Columbia, Canada (Local)
Sean Brady covers a variety of local topics, including government announcements and events related to entertainment, business & industry, education, and heritage in Kamloops. His articles often cite data or provide coverage of governmental motions and decisions.
If you're looking to reach out to Sean with a pitch, consider offering insights or access related to local events such as theater productions, educational initiatives or developments within the gaming industry. Additionally, if your organization is involved in any heritage-related activities or has news relevant to Kamloops' business sector that includes substantial data backing it up, it could be of interest to him.
Since Sean focuses on the local scene in Canada (specifically British Columbia and Kamloops), pitches should align with this geographic focus for maximum relevance.
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The Kamloops Heritage Society is an independent group focused on promoting multicultural heritage in the city
After 96 years of operation, St. George’s Anglican Church has closed. KTW attended the final service in the oldest parish on the North Shore
The annual KamCon gaming convention will take place at Thompson Rivers University from Oct. 13 to Oct. 15
Cole Hickson and Jo Kang were elected to the board a year ago this month
By: Sean Brady
'Gaslight' premieres Oct. 19 and runs to Oct. 28
Students from Brock middle and South Kamloops secondary will travel to Toronto in May 2024
The 670-metre pathway would connect Sixth Avenue to Second Avenue at a projected cost of $2.75 million
By: Amanda Kasper, Sean Brady, Abir Bhattacharjee, Yozen Hernandez, Mai Takahashi, Melinda Ternei, Adrian Morales
DNA topoisomerases are attractive targets for anticancer agents. Dual topoisomerase I/II inhibitors are particularly appealing due to their reduced rates of resistance. A number of therapeutically relevant topoisomerase inhibitors are bacterial natural products. Mining the untapped chemical diversity encoded by soil microbiomes presents an opportunity to identify additional natural topoisomerase inhibitors. Here we couple metagenome mining, bioinformatic structure prediction algorithms, and chemical synthesis to produce the dual topoisomerase inhibitor tapcin. Tapcin is a mixed p-aminobenzoic acid (PABA)-thiazole with a rare tri-thiazole substructure and picomolar antiproliferative activity. Tapcin reduced colorectal adenocarcinoma HT-29 cell proliferation and tumor volume in mouse hollow fiber and xenograft models, respectively. In both studies it showed similar activity to the clinically used topoisomerase I inhibitor irinotecan. The study suggests that the interrogation of soil microbiomes using synthetic bioinformatic natural product methods has the potential to be a rewarding strategy for identifying potent, biomedically relevant, antiproliferative agents.
By: Sean Brady, Michael Chiesa
Trying to identify this steering gear/box we have on hand. The part number is G-3643311, I can find part number G-3643333 which is close. Any idea where I can search to find out what this box is out of. Thanks
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