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Sumedha Tripathi
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Sumedha Tripathi

Writer

AS SEEN ON
Cureus Journal of Medical Science

Preston's Summary

Sumedha Tripathi is a Writer at Indiatimes, where she builds, coordinates, and crafts engaging content for the lifestyle brand 'Evolve.' Her work focuses on a variety of topics including mental health, relationships, self-improvement, and skin care, often collaborating with experts to provide well-structured insights. Sumedha's expertise has been featured in MSN, The Economic Times, and the Cureus Journal of Medical Science.

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Geo Focus

Coverage Attributes:

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Informative: 100 %

Themes Covered:

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Most Recent Topics:

  • Fashion
  • Lifestyle
  • Astrology
  • Health
  • Entertainment
  • Self-improvement

Pitching Insights

Sumedha's articles cover a variety of lifestyle topics, including astrology, health and wellness, travel, and self-improvement. The majority of her coverage pertains to house & home-related content.

To effectively reach out to Sumedha with relevant pitches, consider offering expert insights or data-backed information related to astrology (horoscopes), winter-related topics such as seasonal health tips or travel advice for the colder months. Pitches focusing on how-to guides around home improvement or family activities could also be well-received.

Since she has a national focus on India, tailoring pitches that resonate with Indian culture and traditions would likely increase their appeal.

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Articles

Cureus Journal of Medical Science

Methylenetetrahydrofolate Reductase and Methionine Synthase Reductase Polymorphisms: Genetic Predictors of Congenital Heart Disease Subtypes

Methylenetetrahydrofolate Reductase and Methionine Synthase Reductase Polymorphisms: Genetic Predictors of Congenital Heart Disease Subtypes

By: Sumedha Tripathi, Shalini Tripathi, Akhil K. Sharma, Shally Awasthi, Shalini Tripati, Amita Jain

Objectives: The objective of this study was to investigate the association of methylenetetrahydrofolate reductase (MTHFR c.677C>T) and methionine synthase reductase (MTRR c.66A>G) genetic polymorphisms with the occurrence of congenital heart disease (CHD) and its subtypes in children.Materials and methods: This was a hospital-based case-control which included patients aged 0-11 months hospitalized between July 2022 and December 2023 with an echocardiographically confirmed CHD, and healthy age-matched controls recruited from the immunization clinic, after informed parental consent. Genotyping for MTHFR c.677C>T and MTRR c.66A>G was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results: A total of 245 cases (73 (29.8%) female infants) and 245 controls (77 (31.4%) female infants) were included. MTHFR c.677C>T (TT genotype, OR = 2.75, 95%CI: 1.6-4.5) and MTRR c.66A>G (GG genotype, OR = 2.62, 95%CI: 1.6-4.0) were associated with CHD. Subtype analysis showed a higher risk for ventricular septal defect (VSD) (OR = 5.67, 95%CI: 3.1-10.0 ), atrial septal defect (ASD) (OR = 9.51, 95%CI: 4.9-18.4), and patent ductus arteriosus (PDA) (OR=15.52, 95%CI: 7.1-33.7) for MTHFR c.677C>T, while MTRR c.66A>G was associated with ASD (OR = 8.67, 95%CI: 4.9-15.0) and PDA (OR = 18.54, 95%CI:9.3-36.9). The T allele of MTHFR c.677C>T and the G allele of MTRR c.66A>G were significantly more common in CHD cases (OR= 1.73, 95%CI: 1.3-2.2 and OR= 1.85, 95%CI: 1.4-2.3, respectively) compared to controls.Conclusion: MTHFR c.677C>T and MTRR c.66A>G polymorphisms are associated with increased CHD risk, particularly in VSD, ASD, and PDA. The higher prevalence of T and G alleles in CHD cases suggests their potential role as genetic risk factors, emphasizing their relevance in CHD susceptibility and risk assessment.

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