Thao Nguyen

Editor's Note: This page is a summary of news on the Francis Scott Key Bridge collapse for Tuesday, March 26. For the latest news on the collapse, view our live updates file for Wednesday, March 27.

USA TODAY A calf was attacked and killed in Colorado, wildlife officials said Wednesday, confirming the first gray wolf depredation since the in the state last December.

Eight men were charged with stealing thousands of dollars worth of beer from railroad cars and storage facilities located throughout the Northeast.

USA TODAY Eight men have been charged with stealing at least hundreds of thousands of dollars worth of beer, mostly imported from Mexico, from

SAVANNAH, Ga. — An endangered North Atlantic right whale found dead off the coast of Virginia last month suffered fatal injuries consistent with a

MAURICE RIVER TWP., N.J. — More than 120 dogs were rescued and eight people were charged in connection to a suspected dogfighting network that operated throughout multiple properties in southern New Jersey, authorities said.

Several mutations that cause Parkinson's disease (PD) have been identified over the past decade. These account for 15–25% of PD cases; the rest of the cases are considered sporadic. Currently, it is accepted that PD is not a single monolithic disease but rather a constellation of diseases with some common phenotypes. While rodent models exist for some of the PD-causing mutations, research on the sporadic forms of PD is lagging due to a lack of cellular models. In our study, we differentiated PD patient-derived dopaminergic (DA) neurons from the induced pluripotent stem cells (iPSCs) of several PD-causing mutations as well as from sporadic PD patients. Strikingly, we observed a common neurophysiological phenotype: neurons derived from PD patients had a severe reduction in the rate of synaptic currents compared to those derived from healthy controls. While the relationship between mutations in genes such as the SNCA and LRRK2 and a reduction in synaptic transmission has been investigated before, here we show evidence that the pathogenesis of the synapses in neurons is a general phenotype in PD. Analysis of RNA sequencing results displayed changes in gene expression in different synaptic mechanisms as well as other affected pathways such as extracellular matrix-related pathways. Some of these dysregulated pathways are common to all PD patients (monogenic or idiopathic). Our data, therefore, show changes that are central and convergent to PD and suggest a strong involvement of the tetra-partite synapse in PD pathophysiology.

More than half of the most challenged books in 2023 contained LGBTQ themes or characters, the American Library Association announced Monday in its annual list of most targeted titles.

More than 200 chemical plants nationwide will be required to reduce toxic emissions linked to cancer under a rule issued by the U.S. Environmental Protection Agency on Tuesday.

Recent criminal cases represent a new level of accountability in the country's gun violence epidemic