Van Allen

The limited added benefit of immune checkpoint inhibitors in breast cancer indicates the pressing need to identify biomarkers of response to minimize risk and maximize benefit.

When we look back at the lives of our ancestors, daily life demanded constant problem solving, resilience, and adaptability. Children learned to take care of themselves, work together, and face challenges head on because survival depended on it. Today, our lives are safer, more structured, and more convenient. We have removed many of the obstacles that once shaped resourcefulness and independence and in doing so, we have removed the small daily struggles that build the same qualities in our children.

Abstract: Despite high performance on clinical benchmarks, large language models may reach correct conclusions through faulty reasoning, a failure

South Carolina leaders saw fit to adapt a withholding incentive for hybrid and remote office work scenarios. Photo of Columbia, South Carolina, by Sean Pavone: Getty Images

Integrated knowledge translation (iKT) still relies on static reports, presentations, and manuscripts that cannot adapt to decision-makers' evolving questions. Retrieval-augmented large language models (LLMs) can add a secure, auditable conversational layer over curated program outputs and selected research materials, enabling rapid, traceable synthesis between meetings and across portfolios. Treating these tools as governed infrastructure, with mandatory provenance, privacy protections, transparent documentation, and equity-by-design, could help reduce friction in evidence exchange and shorten the lag between knowledge creation and use.

Abstract Purpose: Computational pathology has emerged as an attractive option for improving risk stratification in prostate cancer (PCa), but