Yan Li

Abstract Background: Neighborhood revitalization is a process through which land use rezoning and capital investment can spur new resources, such

Abstract Background Chikungunya fever (CF), an arthropod-borne disease caused by Chikungunya virus (CHIKV), is a serious public health threat globally.

Affiliations & Notes Clinical Pharmacology and Pharmacometrics, Bristol Myers Squibb, Summit, NJ Article Info Publication History:

The Mn-catalyzed cross-coupling reaction of alcohols is an effective strategy for the synthesis of substituted quinolines. To understand the reaction mechanism, a density functional theory (DFT) study was carried out on the reaction of 2-aminobenzyl alcohol and 2-phenylethanol. The reaction is mainly composed of three processes: (1) the dehydrogenation of 2-aminobenzyl alcohol to produce 2-aminobenzyl aldehyde and catalyst regeneration, (2) the dehydrogenation of 2-phenylethanol to form 2-phenylacetaldehyde and catalyst regeneration, and (3) the C‒N coupling of 2-aminobenzyl aldehyde and 2-phenylacetaldehyde to produce 3-substituted quinoline. For catalyst regeneration (processes 1 and 2), the 2-aminobenzyl alcohol-assisted dehydrogenation is more favorable compare to either direct dehydrogenation or 2-phenylethanol-assisted dehydrogenation. The proton transfer in process 3 was identified as the rate-controlling step, with an energy barrier of 23.9 kcal/mol. The solvent effects were also examined. The mechanistic insights gained in this study would be helpful in improving the current reaction system or designing new reactions.

We present a pathology-responsive, activity-based prodrug strategy that tackles multiple hallmarks of Alzheimer's disease (AD). Rationally designed BE compounds convert under oxidative stress into re...

The exchange of greenhouse gases and air pollutants between the atmosphere and wetlands remains a critical yet poorly understood component of the global climate system. We present fluxes of carbon, nitrogen, and sulfur (FluxCANS), a comprehensive field campaign conducted at the Baiyangdian wetland in the North China Plain, designed to address this knowledge gap. Using a unique combination of advanced measurement techniques including eddy covariance and dynamic flux chambers, we simultaneously tracked the movement of carbon, nitrogen, and sulfur compounds. The results reveal that temperate wetlands act as a “double-edged sword” for the atmosphere. They function as strong sources of greenhouse gases, with reed-covered areas emitting methane (CH ) at rates ∼6 times higher than open water. Conversely, they serve as powerful “cleansers” actively removing reactive pollutants like ozone (O ) and ammonia (NH ) from the air. These findings demonstrate that wetlands do more than store carbon; they actively shape regional air quality and climate feedbacks. This study provides essential real-world data to improve coupled weather and climate models, offering new insights into managing these complex ecosystems under human pressures.

Yilong Li [1] Kaiyuan Zhang [2] Lian Wang [3] Weiping Yao [1] Wenjing Fei [4] Keyu Cheng [5] Guichun Huang

Three bacterial strains, YIC-464 T (isolated from the intestinal tract of Perna mussels), YIC-310 T and YIC-80 (both isolated from rhizosphere soil), were obtained from a seagrass bed in Weihai, PR China. A polyphasic taxonomic study revealed that strains YIC-464 T and YIC-310 T represent two novel species within the genus Arcobacter

ABSTRACT Objective To investigate the incidence and treatment of cerebrospinal fluid leakage due to late presentation of dural

, Yan Li , Shuqing Luo Research output Contribution to journal › Article › peer-review Abstract