By: Yan Jiang, Mingyue Wen, Bo Zhang, Yan Wang, Xuetao Cao, Yixian Li, Henan Xu, Qianjin Lu, Xiao Zhang, Bo Li, Juan Liu, Yi Yu, Xuan Zhang, Xin Wang
Highlights • Spermine restrains JAK1-mediated type I/II cytokine signaling • Spermine occupies JAK1 N-terminal pockets to limit its binding to the receptors