Yuan Yang

The bond market’s big-picture assessment of the country’s finances offers lessons for the government

In recent years, organic dye contamination has posed a significant threat to water safety.

Healthy soil serves as the fundamental basis for sustainable Panax notoginseng (Burkill) F.H.

The respiratory mucosal system plays a critical role in the pathogenesis of allergic asthma (AA). Currently, therapeutic Fc fusion proteins are as a promising strategy for mucosal vaccine delivery systems. In this work, a plasmid encoding the Mycobacterium tuberculosis ESAT6-Fc fusion protein was successfully constructed, and high-purity ESAT6-Fc fusion protein was subsequently obtained. Administered via intranasal immunization in OVA-induced allergic asthma model mice, ESAT6-Fc fusion protein significantly alleviated airway inflammation and mucus production, and reduced the proportions of Th2 cells, Th17 cells, and eosinophils, while increasing the proportions of Th1 cells with no histopathological changes to major organs. To elucidate the underlying immune regulatory mechanisms of ESAT6, integrated transcriptomic and proteomic analyses were performed, revealing Th1/Th2 cell differentiation and Th17 cell differentiation as the two most significantly enriched pathways at both the gene and protein levels. CD3e (CD3E) and CD3g (CD3G), two essential subunits of the TCR–CD3 complex, were identified as core target factors. The validations from the ESAT6-Fc-treated AA lung tissues, as well as co-cultured TH0 cells from C57BL/6J mice and CD2.4 dendritic cells exposed to the ESAT6-Fc protein, were consistent with the aforementioned findings. ESAT6-Fc exhibits a safe profile with favorable efficacy against OVA-induced AA via intranasal immunization, and ESAT6 ameliorates AA by regulating the differentiation of Th0 cells into Th1 cells, which were closely associated with the down-regulation of CD3e and CD3g expression, presumably leading to the impairment of TCR–CD3 complex assembly. ESAT6-Fc fusion protein demonstrates promise as a potential safe intranasal immunotherapy agent for the treatment of AA.

Yuan Yang, the Labour MP for Earley and Woodley, welcomes the introduction of a Reading-wide crackdown on anti-social behaviour.

Mutual misunderstanding and panicky commentary mask a joint desire to see the UK economy doing better

Alzheimer's disease (AD) is closely associated with cholinergic dysfunction, with acetylcholinesterase (AChE) as a key biomarker. Here, a dual-mode colorimetric/fluorescent platform based on PCN-224-Pt nanozyme and LMB-PEG is developed, enabling rapid, sensitive AChE detection with broad linear ranges, low l

In this month's letter, Yuan Yang, the Labour MP for Earley and Woodley, hails the successes and uniformity that Great British Railways brings.

Objective To determine whether an elevated head position (30-40°) improves functional outcomes compared with a flat head position (0-10°) in patients with acute ischaemic stroke caused by anterior circulation large vessel occlusion who have achieved successful reperfusion after endovascular thrombectomy.Design Multicentre, prospective, randomised, open label, blinded endpoint clinical trial.Setting 67 comprehensive stroke centres in China, between 16 November 2023 and 23 January 2025.Participants 1368 adults (aged ≥18 years) with acute ischaemic stroke caused by anterior circulation large vessel occlusion who achieved successful endovascular reperfusion, defined as an expanded thrombolysis in cerebral infarction score ≥2b after endovascular thrombectomy.Interventions Participants were randomly assigned (1:1) to maintain either an elevated head position (30-40°, n=685) or a flat head position (0-10°, n=683) for 72 hours after endovascular thrombectomy.Main outcome measures The primary outcome was functional status at 90 days after randomisation, assessed by shift analysis of scores on the modified Rankin scale (range 0-6). The primary safety outcome was all cause mortality at 90 days after randomisation. Efficacy analyses used the randomised, full analysis set, and safety analyses used the safety population (identical to the randomised population). Adjusted models included age, baseline National Institutes of Health Stroke Scale score (NIHSS), baseline Alberta Stroke Programme Early Computed Tomography Score, occlusion site, and time from last known well (ie, the last time when the patient was known to be at their usual neurological baseline before the current stroke event) to randomisation.Results In the population of 1368 randomised patients, the median age was 68 years, 565 participants (41.3%) were women, and 1358 (99.3%) completed the 90 day follow-up. The median baseline NIHSS score was 15, the median 90 day modified Rankin scale score was 3 (interquartile range (IQR) 1-5) in the head elevation group versus 3 (IQR 1-5) in the flat head position group (adjusted generalised odds ratio for a lower level of disability 1.12, 95% confidence interval (CI) 0.97 to 1.29, P=0.14). All cause mortality at 90 days occurred in 125 (18.3%) of 682 patients in the elevated head position group and 137 (20.3%) of 676 patients in the flat head position group (adjusted risk ratio 0.86, 95% CI 0.69 to 1.07, P=0.18).Conclusions 72 hours of head elevation did not significantly improve 90 day functional outcomes versus flat head positioning in patients who had acute ischaemic stroke from large vessel occlusion with successful reperfusion after thrombectomy. The smaller than expected difference in results between the two groups leaves open the possibility of a modest but clinically meaningful benefit of head elevation in these patients.Trial registration ClinicalTrials.gov [NCT06115707][1].Data sharing: The code used to analyse the data in the paper can be found in the supplementary appendix. The data underlying the findings in this paper are openly and publicly available and can be found here: . Data queries should be addressed to the corresponding author.[1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT06115707&atom=%2Fbmj%2F394%2Fbmj-2026-100363.atom

Yuan Yang, the Labour MP for Earley and Woodley, welcomes the steps to help young people move forward and care for the elderly.