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Abu Bakar
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Abu Bakar

AS SEEN ON
sportda.com, Paperity, MDPI, Nature Portfolio

Preston's Summary

Abu Bakar is a versatile journalist who writes for various publications including MDPI, Oxford University Press, and the Royal Society of Chemistry. With a wide range of interests, Abu covers topics such as gaming, machine learning, spectroscopy, sports, advocacy, interior design, and public health. Abu's work has been featured in prestigious journals and media outlets, showcasing their expertise in diverse fields.

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Geo Focus

United States (National)

Coverage Attributes:

Beta
Cites Data: 17 %
Industry Specific: 17 %
Expert Commentary: 12 %
Press Release: 8 %
Announcement: 7 %

Themes Covered:

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Most Recent Topics:

  • Sports Disciplines
  • Environmental Services
  • Corporate Sustainability
  • Energy Sustainability

Pitching Insights

Abu Bakar's coverage primarily revolves around sports, particularly soccer betting and online gambling. While his articles touch on a wide range of topics, he seems to have an emphasis on the intersection between technology and gambling.

Considering this, it's likely that Abu Bakar would be receptive to pitches related to expert commentary or industry-specific insights regarding developments in the world of sports betting and online casino gaming. Experts with knowledge about the technological advancements shaping these industries may find success when reaching out for potential collaborations or interviews.

Given the variety of topics covered by Abu Bakar, experts from fields such as electrical engineering (related to technology in casinos), environmental analysis (in relation to groundwater), and even refugee studies could potentially provide valuable insights within their respective areas when approaching him.

This information evolves through artificial intelligence and human feedback. Improve this profile .

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Articles

MDPI

Intraperitoneal Injection of the Porphyromonas gingivalis Outer Membrane Vesicle (OMV) Stimulated Expressions of Neuroinflammatory Markers and Histopathological Changes in the Brains of Adult Zebrafish

Intraperitoneal Injection of the Porphyromonas gingivalis Outer Membrane Vesicle (OMV) Stimulated Expressions of Neuroinflammatory Markers and Histopathological Changes in the Brains of Adult Zebrafish

By: Azmai, Malik, Teoh, Hamarsha, Akinsola, Abu Bakar, Rasaq, Nasruddin, Nurrul Shaqinah, Adewoyin, Ahmed, Noraini, Seong Lin, Mohammad Noor Amal

Porphyromonas gingivalis is the major pathogenic bacteria found in the subgingival plaque of patients with periodontitis, which leads to neuroinflammation. The bacteria destroy periodontal tissue through virulence factors, which are retained in the bacteria’s outer membrane vesicles (OMV). This study aimed to determine the real-time effect of an intraperitoneal injection of P. gingivalis OMV on the production and expression of inflammatory markers and histopathological changes in adult zebrafishes’ central nervous systems (CNS). Following the LD50 (21 µg of OMV), the zebrafish were injected intraperitoneally with 18 µg of OMVs, and the control group were injected with normal saline at seven different time points. Brains of experimental zebrafish were dissected at desired time points for colorimetric assays, ELISA, and histology. This study discovered that nitric oxide and PGE2 were significantly increased at 45 min, while IL-1β and IL-6 were expressed at subsequent 12 h and 24 h time points, respectively. Histopathological changes such as blood coagulation, astrocytosis, edema, spongiosis, and necrosis were observed between the 6hour and 24 h time points. The two apoptotic enzymes, caspases 3 and 9, were not expressed at any point. In summary, the OMV-induced neuroinflammatory responses and histopathological changes in adult zebrafish were time-point dependent. This study will enrich our understanding of the mechanism of P. gingivalis OMVs in neuroinflammation in a zebrafish model, most especially the timing of the expression of inflammatory mediators in relation to observable changes in brain tissues.

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