Adrian Morales

The Asus ROG Ally seems to be a strong competitor in the handheld PC space, but it must address the biggest roadblocks in the market to succeed.

Before fans can get their hands on Minecraft Legends and start building and strategizing with friends, there are some things they should know.

Crafting and gathering in Minecraft Legends now relies on the Allay mob type, and there are a couple of ways to find them so players can build more.

Lies of P’s demo shows off a compelling world dripping with atmosphere while its gameplay trades blows with the best in the soulslike genre.

The Corsair K65 Pro Mini is a 65% keyboard that excels in performance and responsiveness while also improving its acoustic profile significantly.

Atlas Fallen has some interesting world-building and lore, but a boring story, lackluster performances, and stale combat make this game a total slog.

Cyclic oligonucleotide-based antiphage signalling systems (CBASS) protect prokaryotes from viral (phage) attack through the production of cyclic oligonucleotides, which activate effector proteins that trigger the death of the infected host 1, 2

Game Rant goes hands-on with the atmospheric Pacific Drive, which seems to be taking the rogue-like genre on a road trip it won’t soon forget.

DNA topoisomerases are attractive targets for anticancer agents. Dual topoisomerase I/II inhibitors are particularly appealing due to their reduced rates of resistance. A number of therapeutically relevant topoisomerase inhibitors are bacterial natural products. Mining the untapped chemical diversity encoded by soil microbiomes presents an opportunity to identify additional natural topoisomerase inhibitors. Here we couple metagenome mining, bioinformatic structure prediction algorithms, and chemical synthesis to produce the dual topoisomerase inhibitor tapcin. Tapcin is a mixed p-aminobenzoic acid (PABA)-thiazole with a rare tri-thiazole substructure and picomolar antiproliferative activity. Tapcin reduced colorectal adenocarcinoma HT-29 cell proliferation and tumor volume in mouse hollow fiber and xenograft models, respectively. In both studies it showed similar activity to the clinically used topoisomerase I inhibitor irinotecan. The study suggests that the interrogation of soil microbiomes using synthetic bioinformatic natural product methods has the potential to be a rewarding strategy for identifying potent, biomedically relevant, antiproliferative agents.

Abstract Gonorrhea, which is caused by Neisseria gonorrhoeae, is the second most prevalent sexually transmitted infection worldwide.