Andrea S

Adding isatuximab to carfilzomib and dexamethasone does not improve overall survival in patients with relapsed/refractory multiple myeloma, data from the IKEMA trial suggest.

Among US patients with Ph+ CML, those with lower incomes have not derived the same benefits from therapeutic advances as those with higher incomes.

In the first stage of the BR.36 adaptive trial in patients with non-small cell lung cancer receiving anti-PD1 immunnotherapy, the primary endpoint of concordance between circulating tumor DNA (ctDNA) molecular response and RECIST response was met. The results will inform the second, ctDNA-directed stage.

Privately-insured cancer patients living in states with restrictive telehealth policies were less likely to use telehealth in 2020 and 2021, a study showed.

In a recent survey, 70% of cancer patients said they use complementary or alternative medicine as part of their cancer care.

Individual participant data packages for cancer trials are often incomplete, a new study suggests.

Results from the PATHFINDER study suggest that MCED testing is feasible in practice, but more research is needed to assess its clinical utility.

The process of follicle maturation leading to ovulation is a key milestone in female fertility. It is known that circulating lipids and cytokines play a role in the follicle’s ability to go through follicular maturation and the ovulatory processes. However, the specific mechanisms are not well understood. We posit that dysregulation of granulosa cells influences the ovarian environment, which tries to adapt by changing released lipids and cytokines to achieve follicular maturation. Eleven non-lactating adult females underwent estrus synchronization with two injections of PGF2α 14 days apart. Daily blood samples were collected for 28 days to monitor steroid hormone production after the second injection. To understand the potential impacts of lipids and cytokines during ovulation, a low-dose FSH stimulation (FSHLow) was performed after resynchronization of cows, and daily blood samples were collected for 14 days to monitor steroid hormone production until ovariectomies. The lipidomic analysis demonstrated increased circulating diacylglycerides and triacylglycerides during the mid-luteal phase and after FSHLow treatment. Cholesteryl esters decreased in circulation but increased in follicular fluid (FF) after FSHLow. Increased circulating concentrations of TNFα and reduced CXCL9 were observed in response to FSHLow. Therefore, specific circulating lipids and cytokines may serve as markers of normal follicle maturation.

Adding berzosertib to topotecan improves overall survival, but not progression-free survival, in patients with relapsed small cell lung cancer, a phase 2 trial suggests.

Abstract Quality control procedures play a pivotal role in ensuring the reliability and consistency of data generated in mass spectrometry-based proteomics laboratories.