Andrea Smith

A recent study found certain workouts can help with PPD. St. Louis area experts comment on the findings.

In my hands-on test, the OnePlus 13 impressed me with its IP69 durability, Aqua Touch screen usability when wet, and long-lasting 6,000mAh battery tech.

Ghrelin enhances feeding by activating the growth hormone secretagogue receptor (GHSR). In the brain, GHSRs are expressed in regions responsible for regulating food motivation including the ventral tegmental area (VTA). Endogenous cannabinoids also promote food seeking behaviors through the cannabinoid receptor 1 type (CB-1Rs) in brain regions including the VTA. It is not known, however, if ghrelin and endocannabinoids interact in the VTA to produce these effects. We therefore examined if GHSR and CB-1R interact within the VTA to enhance food motivation. Results show that GHSR and CB-1R mRNA are expressed in the VTA cells in male and female rats and mice, with the GHSR being expressed in dopamine cells, and the CB-1R being expressed primarily in non-dopaminergic cells with no obvious sex differences. Ghrelin directly activated and increased excitatory tone onto dopamine cells of male and female mice. Male rats lacking fully functional GHSR signalling showed disrupted gene expression of transcripts important for regulating the synthesis, release, and degradation of endocannabinoids and lowered the levels of 2-arachidonoylglycerol (2-AG) within the VTA. Moreover, pharmacological antagonism of VTA CB-1Rs attenuates the orexigenic and appetitive effects of intra-VTA ghrelin in rats and blocks the ability of ghrelin to promote excitatory drive to VTA dopamine neurons. Finally, blocking the breakdown of cannabinoids in the VTA enhances the effects of ghrelin on food motivation. Together, our data show that ghrelin stimulates VTA dopamine cells and ultimately food motivation in part through a mechanism that involves endocannabinoid signalling at the CB-1R.

India's software development industry is renowned for its innovation and world-class talent. While large IT giants often dominate the spotlight, mid-sized companies play a crucial role in driving digital transformation for startups, SMEs, and enterprises. These mid-sized software development firms offer personalized services, specialized expertise, and cost-effective solutions, making them ideal partners for a wide range of tech projects. In this article, we highlight some of the top mid-sized software development companies in India.

Make your event more inclusive by providing sweet treats that gluten- and dairy-free guests can enjoy too.

School was not a good experience for me. I really struggled and had difficult experiences with teachers who just didn’t like me, and who maybe didn’t recognise that I wasn’t there yet in terms of maturity or ability.

My job is arranging weddings for couples who want to get married in Central Park. At this stage, I’ve worked with hundreds of Irish couples.

After seven years with a luxury design-build construction firm in the St. Louis area, McAvin says that “going out on my own feels liberating.”

Want to try a new group-fitness experience this year? These classes will have you focused more on high-energy music than on your tired muscles.