Anjali Krishnan

Meet Alakh Pandey, whose startup PhysicsWallah raised $100 million to join the list of unicorns in India.

Should you switch to black salt or pink salt? Nutritionist Amita Gadre breaks myths and lays down facts about choosing the right salt.

The Delhi-based startup collects used cooking oils from restaurants and converts them into biodiesel, generating lower carbon emissions.

T Jayalakshmi, a former teacher from Visakhapatnam makes edible tea cups using ragi and rice flour. Today, she manufactures around 30,000 to 40,000 cups per month.

Architect Joseph Mathew from Pathanamthitta, Kerala sourced old wood, roof tiles, and stones from demolished schools to build his dream home.

Hoovu, a subscription-based startup for puja flowers by Yeshoda and Rhea Karuturi from Bengaluru is revolutionising the traditional flower market in India.

Directed by Pan Nalin, the Gujarati film ‘Chhello Show’ is shortlisted at Oscars 2023 in the International Feature film category.

Aman Sharma, a 19-year-old from Delhi started Cuckoo About Nature Club — a birding club by youth for youth. He grows over 500 plants in his terrace garden, which invite birds, butterflies and bees.

Cerebral processes contribute to pain beyond the level of nociceptive input and mediate psychological and behavioural influences. However, cerebral contributions beyond nociception are not yet well characterized, leading to a predominant focus on nociception when studying pain and developing interventions. Here we use functional magnetic resonance imaging combined with machine learning to develop a multivariate pattern signature—termed the stimulus intensity independent pain signature-1 (SIIPS1)—that predicts pain above and beyond nociceptive input in four training data sets (Studies 1–4, N =137). The SIIPS1 includes patterns of activity in nucleus accumbens, lateral prefrontal and parahippocampal cortices, and other regions. In cross-validated analyses of Studies 1–4 and in two independent test data sets (Studies 5–6, N =46), SIIPS1 responses explain variation in trial-by-trial pain ratings not captured by a previous fMRI-based marker for nociceptive pain. In addition, SIIPS1 responses mediate the pain-modulating effects of three psychological manipulations of expectations and perceived control. The SIIPS1 provides an extensible characterization of cerebral contributions to pain and specific brain targets for interventions.

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