Asma Khalid

President Biden tours the Museu da Amazonia, a rainforest preserve in Manaus, Brazil, on Nov. 17, 2024, before heading to Rio de Janeiro for the G20 Summit.

“Some may seek to deny or delay the clean energy revolution that’s underway in America, but nobody — nobody — can reverse it,” Biden said. But Trump has vowed to roll back those plans.

Chronic kidney disease (CKD) has shown a growing association with osteoporosis, comprising part of the broader CKD-mineral and bone disorder (CKD-MBD). CKD-MBD is marked by alterations in calcium, phosphorus, parathyroid hormone (PTH), and vitamin D metabolism, significantly elevating fracture risk. While traditional osteoporosis treatments such as bisphosphonates, denosumab, and teriparatide have been adapted for CKD patients, recent innovations have introduced agents aimed at enhancing bone mass and reducing fracture incidence. This study aims to evaluate the pathophysiology, diagnostic methods, and tailored management strategies for osteoporosis in CKD patients. A detailed review of the literature was conducted, involving an in-depth search of PubMed, Medical Literature Analysis and Retrieval System Online (MEDLINE), and the Cochrane Library databases for studies published between 2017 and 2024. Studies were selected based on inclusion criteria focusing on CKD-related osteoporosis, diagnostic criteria, and treatment outcomes. Data extraction and quality assessment were independently performed by multiple reviewers to ensure thoroughness and reduce bias. Findings highlight that conventional treatments, such as bisphosphonates, denosumab, and teriparatide, when tailored to CKD stages, demonstrate variable effectiveness in lowering fracture risk.Additionally, emerging pharmacologic agents hold promise in improving bone density, though evidence on these newer therapies remains limited. Osteoporosis management in CKD patients necessitates a personalized approach guided by the disease's stage and individual profile. This review underscores the potential of emerging therapies and emphasizes the need for further research to refine treatment protocols, aiming to enhance patient outcomes in this complex population.

President Biden's move to pardon his son Hunter has been met with criticism — from opponents and some allies. We look at what that means for his legacy.

One of the last two Sam Goody record stores will close in early 2025. NPR's Asma Khalid talks to Rolling Stone's David Browne about why he says it was more than just another store at the mall.

NPR's Asma Khanlid talks to ESPN's Howard Bryant about baseball legend Rickey Henderson, one of MLB's all-time greatest. He's the author of: "Rickey: The Life and Legend of an American Original."

Biden commutes the sentences of 3,740 people on federal death row. NIH invests $300 million to research treatments for long COVID. Officials in Lebanon assess war's damage to cultural heritage sites.

With the Christmas release of the movie about Bob Dylan -- "A Complete Unknown" -- we consider what elements make for a great music biopic... and why some films hit a sour note.

The federal government remains open for business. That's because Congress managed to avoid a government shutdown on Friday that would have hit families right before the holidays.

ASMA KHALID, HOST: Major League Baseball's stolen base king and one of its most flamboyant stars has died. (SOUNDBITE OF ARCHIVED RECORDING)