Deeksha Sharma

Controversial media personality Andrew Tate is now free to travel anywhere in Romania, thanks to a court that eased the travel restrictions against him.

High summer heat and poor winter snowfalls have cost Switzerland 10% of its glaciers. Experts have described the event as "catastrophic."

China snubbed a German climate envoy this week in what is speculated to be a retaliatory move over the German foreign minister's remarks against Xi Jinping.

In a world of chic skincare, the nostalgic allure of Vaseline, Boroline, and Kailas Jeevan endures; here’s what makes them so special

Congress leader Sowmya Reddy is all set to contest against BJP’s Tejasvi Surya from Bangalore South, know all about her

Breast cancer patients with estrogen receptor positive tumors face a constant risk of disease recurrence for the remainder of their lives. Dormant tumor cells residing in tissues such as the bone marrow may generate clinically significant metastases many years after initial diagnosis. Previous studies suggest that dormant cancer cells display “stem like” properties (CSCs), which may be regulated by the immune system. To elucidate the role of the immune system in controlling dormancy and its escape, we studied dormancy in immunocompetent, syngeneic mouse breast cancer models. Three mouse breast cancer cell lines, PyMT, Met-1 and D2.0R, contained CSCs that displayed both short- and long-term metastatic dormancy in vivo, which was dependent on the host immune system. Each model was regulated by different components of the immune system. Natural killer (NK) cells were key for the metastatic dormancy phenotype in D2.0R cells. Quiescent D2.0R CSCs were resistant to NK cell cytotoxicity, while proliferative CSCs were sensitive. Resistance to NK cell cytotoxicity was mediated, in part, by expression of BACH1 and SOX2 transcription factors. Expression of STING and STING targets was decreased in quiescent CSCs, and the STING agonist MSA-2 enhanced NK cell killing. Collectively, these findings demonstrate the role of immune regulation of breast tumor dormancy and highlight the importance of utilizing immunocompetent models to study this phenomenon.

The crowd of devotees gathered on the streets of Puri to celebrate the Jagannath Rath Yatra Shutterstock Deeksha Sharma

The Yulla Kanda trek is arduous but worthwhile. The sacred energy of the world's highest Lord Krishna temple echoes all around, propelling you upwards with zeal and devotion

The competition between Bhool Bhulaiyaa 3 and Singham has intensified behind the scenes. As of now, there are still uncertainties regarding ticket bookings.

Growing global concerns over reducing carbon emissions in the electricity market have accelerated the integration of renewable energy sources and electric vehicles, increasing variabilities and uncertainties across various nodes of power networks. System planners and operators recognize the importance of probabilistic bulk system reliability assessment methods capable of capturing the real-time behavior of components in the emerging systems. In this regard, the paper proposes a methodology for conducting bulk system reliability assessments of power system networks characterized by variable supply and demand profiles at different bulk power points. This paper implements a nodal negative load modeling method to integrate wind power generation in reliability assessment, capturing the cross-correlation between demand–supply variabilities at any node of the network. The multi-state load model employs the load cut-off strategy to reduce the number of demand scenarios, enhancing the computational efficiency. Moreover, the multi-state wind modeling approach considers the penetration levels, ensuring the impact of increasing penetration is appropriately captured. The methodology determines a list of a reduced set of scenarios for which consequence assessment needs to be conducted. The proposed framework and methods can readily be applied by power utilities, as these methods can be incorporated into most commercial software that uses an analytical approach for CSR assessment. The methodology is illustrated using the Roy Billinton Test System (RBTS) and can be effectively applied to other networks.