Denise Evans

Rufford in Lancashire is full of history and stunning scenery - and the jewel in its crown has to be Rufford Old Hall, a Tudor building surrounded by vivid bluebells in the spring

Introduction Tuberculosis (TB) is a leading infectious cause of death globally. It is the most common opportunistic infection in people living with HIV, and the most common cause of their morbidity and mortality. Following TB treatment, surviving individuals may be at risk for post-TB lung disease. The TB Sentinel Research Network (TB-SRN) provides a platform for coordinated observational TB research within the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium. Methods and analysis This prospective, observational cohort study will assess treatment and post-treatment outcomes of pulmonary TB (microbiologically confirmed or clinically diagnosed) among 2600 people aged >= 15 years, with and without HIV coinfection, consecutively enrolled at 16 sites in 11 countries, across 6 of IeDEA's global regions. Data regarding clinical and sociodemographic factors, mental health, health-related quality of life, pulmonary function, and laboratory and radiographic findings will be collected using standardised questionnaires and data collection tools, beginning from the initiation of TB treatment and through 12 months after the end of treatment. Data will be aggregated for proposed analyses. Ethics and dissemination Ethics approval was obtained at all implementing study sites, including the Vanderbilt University Medical Center Human Research Protections Programme. Participants will provide informed consent; for minors, this includes both adolescent assent and the consent of their parent or primary caregiver. Protections for vulnerable groups are included, in alignment with local standards and considerations at sites. Procedures for requesting use and analysis of TB-SRN data are publicly available. Findings from TB-SRN analyses will be shared with national TB programmes to inform TB programming and policy, and disseminated at regional and global conferences and other venues.

Dunsop Bridge sits right in the middle of the 'little Lake District'

It's one of the most picturesque parts of our beautiful county, but one of it's most 'boringly ugly' features could put it on the map.

Inside a phone box you will find a note marking the middle of the country

A quiet, picturesque countryside has a phone box that has a note to remind visitors they are in the middle of the UK

The untouched village of Downham, Lancashire is on the edge of the Forest of Bowland and one of the most picturesque locations in the Peak District

If you pay a visit to the beautiful rural village of Downham you will be rewarded with gorgeous picture-postcard scenes in an area of outstanding natural beauty, but you may notice some items missing

With the start of the state volleyball tournament just a couple of weeks away we will take a break from the football stories and take a look at one of just three sports that advanced to the state that represented North Montgomery.