Elizabeth Nolan

The drop in teen and young adult suicides is a bright spot among an overall bleak portrait of U.S. suicide rates in 2022.

Plus: New Zealand libertarianism, Barbie economics, and more...

From Denver, another tragic story about cops shooting and killing someone holding a "weapon" that turned out to actually be...

President Joe Biden's approval ratings are especially low when it comes to the economy, according to the latest Associated Press/NORC poll. Just 36 percent of those surveyed said Biden is doing a good job handling the economy.

A new poll attempts to suss out the contours of the Republican Party in 2023. The results suggest it is an ideologically diverse coalition, if also a weird one.

A leaked draft agreement with TikTok would bring U.S. government closer to almost China-style control of the app.

Under the amended bill, striking employees would be eligible for unemployment benefits after two weeks on strike.

The worst of the antitrust alarmism keeps proving untrue, as tech companies believed by some to be monopolies instead lose market share.

Forgive me for starting with some sweeping generalisations about three key personality traits of project professionals, but I hope you’ll be able to relate.

The development of inert, biocompatible chelation methods is required to harness the emerging positron emitting radionuclide 45Ti for radiopharmaceutical applications. Herein, we evaluate the Ti(IV)-coordination chemistry of four catechol-based, hexacoordinate chelators using synthetic, structural, computational, and radiochemical approaches. The siderophore enterobactin (Ent) and its synthetic mimic TREN-CAM, readily form mononuclear Ti(IV) species in aqueous solution at neutral pH. Radiolabeling studies revealed that Ent and TREN-CAM form mononuclear complexes with the short-lived, positron-emitting radionuclide45Ti(IV), and that these complexes do not transchelate to plasma proteins in vitro and exhibit rapid renal clearance in naïve mice. These features guided efforts to target the 45Ti isotope to prostate cancer tissue through the design, synthesis, and evaluation of Ent-DUPA, a small molecule conjugate composed of a prostate specific membrane antigen (PSMA) targeting peptide and a monofunctionalized Ent scaffold. The [45Ti][Ti(Ent-DUPA)]2- complex formed readily at room temperature and in a tumor xenograft model in mice, displayed selective tumor tissue accumulation (8± 5%, n=5), and low off-target uptake in other organs. Overall, this work demonstrates targeted imaging with 45Ti(IV), provides a foundation for advancing the application of 45Ti in nuclear medicine, and reveals that Ent can be repurposed as a 45Ti-complexing cargo for targeted nuclear imaging applications.