Gurpreet Kaur

Filmmakers Kiran Rao and Siddharth Anand talk about how streaming platforms have added on to the lifespan of their films ‘Laapataa Ladies' and ‘Fighter' respectively.

1. Introduction GST was introduced to replace several other indirect taxes implemented by the Central as well as the State Governments.

"With the centralisation of exams, we have only one option to enroll for PhD, and even that is full of snags."

Long periods of waterlogging are a major obstacle to expanding irrigated corn production in vertisols (shrink-swell clay soils) of the Mississippi Delta. This problem can occur when large, unexpected rainfall follows shortly after a conventional application of furrow irrigation. Some growers have responded to this problem by widening furrow irrigation spacing while increasing furrow inflow rate proportionally. Through three years of field experimentation at two sites, this technique was found to maintain or even improve corn grain yield. Grain protein and kernel weight was also observed to be higher in portions of the field where this technique was expected to reduce waterlogging. Therefore, using this technique to implement furrow irrigation spacings of up to 26.7 ft should not lower corn grain yield and quality under conditions similar to this study.

Menopause is a natural phase marked by the permanent cessation of menstrual cycles, occurring when the production of reproductive hormones from the ovaries stops for at least 12 consecutive months. Studies have suggested a potential connection between menopause and a heightened risk of developing Alzheimer's disease (AD), underscoring the significant role of reduced estrogen levels in the development of AD. Estrogen plays a crucial role in brain metabolism, influencing energy metabolism, synaptic plasticity, and cognitive functions. The cognitive benefits associated with hormone replacement therapy (HRT) are believed to be linked to estrogen's neuroprotective effects, either through direct action on the brain or indirectly by improving cardiovascular health. Extensive literature supports the positive impact of estrogen on brain cells. While the physiological effects of estrogen on the brain have not been consistently replicated in clinical trials, further research is crucial to provide more definitive recommendations to menopausal patients regarding the influence of HRT on AD. This review aims to comprehensively explore the interplay between menopause and AD, as well as the potential of HRT to mitigate cognitive decline in post-menopausal individuals.

Abstract Human noroviruses (HuNoVs) are a significant cause of epidemic and sporadic acute gastroenteritis worldwide.

A drug design strategy with reduced side effects and economic feasibility is desirable for fatal diseases. Increasing the bioavailability of a drug using a bioenhancer is a smart strategy. Herbal/natural bioenhancers with no probable side effects are an ideal choice to enhance the pharmacokinetics of a therapeutic drug synergistically. The mechanism of bioenhancers relies on the retention of the drug molecule in the cell without causing any changes in the metabolic activity. Most of the herbal bioenhancers achieve this feat by inhibiting metabolic enzymes such as cytochrome P450 and Uridine 5'-diphospho-glucuronosyltransferase. The efflux pump p-glycoprotein, responsible for removal of xenobiotics, is also inhibited by herbal/natural bioenhancers. The increased bioavailability because of the higher Cmax and tmax of chemotherapeutics or anti-infectious agents such as rifampicin can result in a lower drug dosage regimen. The reduction in drug dosage is directly linked to fewer side effects and economic viability. Further, there is a significant effort in clinical trials to incorporate bioenhancers in drug regimens for cancer. The role of herbal/natural bioenhancers and their potential to augment the bioavailability of therapeutics used in cancer and infectious diseases, with a focus on the mechanisms of action, clinical studies and patents, have been summarized in this review article.

Back in her hometown of Jalandhar, Punjab, Gurmeet Kaur is fondly known as Gopi Nakodar Wali, a name that ties her to the town of Nakodar and her growing fame in kabaddi.

Harpreet Kaur Gurbir Singh Karl Williard Jon Schoonover Kelly A. Nelson

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