By: Jamie Feldman, Jessica Mak, Caterina Gratton, Mary Phillips, Boris Birmaher
Bipolar disorder (BD) is characterized by temporal instability of mood and energy, but the neural correlates of this instability are poorly understood. In previous cross-sectional studies, mania has been correlated with increased functional connectivity (FC) of regions key to reward processing. Here, we assess whether BD is associated with longitudinal instability within a reward-related network of interest (NOI).