John Barron

“Oh, it was a dream come true. It was so cool. A check on my agenda.” Wellington's Cheyenne Morris is 10 years old. And she credits her singing ambition to Olivia Rodrigo.

The ultimate preferred treatment for hepatocellular carcinoma (HCC) complicated with cirrhosis and portal hypertension is an orthotopic liver transplant (OLT). Loco regional therapy (LRT) has emerged to prevent tumor growth and progression of disease beyond the Milan criteria to achieve transplant. There is a paucity of data regarding safety, posttransplant survival benefits, and tumor recurrence rate achieved by these LRT modalities. We aim to assess and compare the five-year survival rate and tumor recurrence rate with or without LRT in patients after OLT with diagnosed HCC utilizing the nation's largest dataset. This is a retrospective observational study approved by Saint Louis University institutional review board. We utilized the largest dataset from the years 2003-2013 where pertaining data were gathered from Organ Procurement Transplant Network (OPTN) standard analysis and research files (STAR) through novel linkages with Medicare bills. Descriptive and comparative statistics were performed. 2412 (51.6%) patients received any form of locoregional therapy (single or combination) out of 4669 total study sample size. The overall five-year survival in the study sample was 76.1%. There was statistically no significant improvement seen in five-year posttransplant survival in the group that received one mode of LRT (adjusted hazard ratio (aHR) 0.97, P<0.64) or a combination of LRT (aHR 0.94, P<0.58) in comparison to those that received none after adjusting donor and recipient clinical characteristics. However, five-year survival trended higher among those treated with combination therapy over those treated with single LRT or none. Overall HCC recurrence was 4.8%, while no significant difference was noted when comparing above-mentioned groups. Five-year posttransplant survival and HCC recurrence rate were also found to have no difference when compared between above-mentioned groups after adjusting explant pathology.This is the largest retrospective study comparing liver transplant patients with HCC who received LRT to none. Although it did not show any statistically significant benefit of single or combination of LRT on survival or tumor recurrence after liver transplant for HCC patients, the outcomes encourage the safe and feasible use of LRT as a bridging therapy. Our study also suggests an observed pattern of improved posttransplant survival and tumor recurrence rate with combination loco-regional therapy. Larger multicenter prospective studies will be required to achieve the effect size to determine the best therapies for maximizing patient survival cost-effectively.

A new year that brings nothing but promise. “Big expectations for the program. Just want try to come out and have a successful season,"said

"Every year is another opportunity to win games and create memories," Dolphins wide receiver Tyreek Hill said. "[We have] a great group of guys.... This is our best team since (I've) been here, so what a time to be alive."

BOCA RATON, Fla. — With a strong 2-0 start so far this high school football season, the West Boca Buls are now focused on a much-needed bye week.

MIAMI GARDENS, Fla. — With the NFL season underway and Week 1 now in the books, WPTV is taking a look at some key players including Miami Dolphins defensive tackle Zach Sieler.

Barron J, Raja S, Murthy S. Robotic Lingulectomy With Firefly-Assisted Bronchoscopic Transillumination. September 2024. doi:10.25373/ctsnet.26972428

BOYNTON BEACH, Fla. — As residents across Florida prepare for Hurricane Helene, Boynton Beach Fire Rescue is sending crews to Central Florida with additional supplies to help communities.

This Dolphins offense has had a tough go these past few weeks, falling to 26th in the league in total yards per game.

SUNRISE, Fla. — The Panthers were hoping to take back a win against the Devils after that 4-1 lose earlier this week.