Juan Pedro

Pediatrics Department, Reference Unit for Rare Diseases DiERCyL, University Hospital of Salamanca, 37007 Salamanca, Spain

Background/Objectives: To analyze the best noninvasive tests prognosis marker in patients with diabetic foot ulcer (DFU) who underwent endovascular revascularization based on clinical outcomes, such as healing rate, time to heal, and free amputation survival after at least a six-month follow-up. Methods: A multicentric prospective observational study was performed with 28 participants with ischemic or neuroischemic DFU who came to the participant centers and underwent endovascular revascularization between January 2022 and March 2023. Toe systolic pressure (TP), ankle systolic pressure (AP), the ankle brachial pressure index (ABPI), the toe brachial pressure index (TBPI), transcutaneous pressure of oxygen (TcPO2), and skin perfusion pressure (SPP) were evaluated using PeriFlux 6000 System, Perimed, Sweden, before (Visit 0) and four weeks after revascularization (Visit 1). The primary clinical outcome was an evaluation of the clinical evolution of noninvasive tests comparing Visit 0 and Visit 1, estimating the sensitivity for predicting wound healing of noninvasive tests at six months following initial recruitment. Results: After six months, 71.43% (n = 20) of DFU healed, four patients (14.3%) received major amputations, and one (3.5%) died. The two tests that best predicted wound healing after revascularization according to the ROC curve were TcPO2 and TP with sensitivities of 0.89 and 0.70 for the cut-off points of 24 mmHg and 46 mmHg, respectively. Conclusions: TcPO2 and TP were the two tests that best predicted wound healing in patients who underwent endovascular revascularization. Clinicians should consider the importance of the evaluation of microcirculation in the healing prognosis of patients with diabetic foot ulcers.

Abstract Background Canine leishmaniosis (CanL), caused by Leishmania infantum , is an important vector-borne parasitic disease in dogs with implications for human health.

Parasites & Vectors , Article number: Cite this article Abstract

Spain has one of Europe's most extraordinary biodiverse environments and a significant risk of fires in its forests. At the same time, rural areas are affected by several challenges, such as desertification, population decrease, and loss of income. Fortunately, some green sparks arise on the horizon. Among them, we use critical enabling technologies for fire prevention and extinction, renewable energy, and resilience solutions by adopting a system of systems approach given by the systems engineering frameworks. We analyse recent Research and Development (R&D) projects focused on fire prevention to detect (1) the key enabling technologies used and (2) engineering practices. A motivational case is presented, which evaluates the potential interest of the mineral water industry sector in applied R&D with key enabling technologies, including the replicability potential and the replicability potential for using the R&D results. After that, the authors initialize an innovative R-ISSUES model to promote early interoperability between energy and environment systems engineering towards the shared mission of designing digital and rural jobs to preserve our biosphere. The model is used to answer specific research questions and detect gaps or potential improvements for the model itself by using the recent scientific literature.

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Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Av. Miguel Grau 755, Lima 15001, Peru

In recent years, the market has seen a growing demand for healthy and convenient food options, such as fruit and cereal bars, driven by shifts in eating habits. These changes are primarily attributed to time constraints in meal preparation and the need for ready-to-eat foods. Consequently, this has promoted interest in creating a nutritious, high-quality snack combining oats and mango. This study employed a response surface analysis of extreme vertex mixtures, incorporating constraints and three components: oats, mango peel, and dehydrated mango pulp. This resulted in ten different mixtures, each with unique combinations and proportions of the three components. It evaluated the microbiological quality, proximal composition, total phenolic content, tannins, Aw, color, texture, and chemical properties during storage at room temperature. The optimal blend, which demonstrated the best quality characteristics, consisted of 44.38% oats, 5.36% mango peel, and 29.24% mango pulp. This formulation yielded a protein content of 7.1 g, dietary fiber of 20.3 g per 100 g, total phenols of 3.4 mg gallic acid per g, and no pathogenic microorganisms. According to the obtained data, Aw > 0.3, the estimated shelf life could be 12 months at room temperature. Developing a stable oat-mango snack with excellent nutritional, nutraceutical, chemical quality, and microbiological properties is technologically feasible.

Open Access Case Report by Juan Pedro Fuentes-García Juan Pedro Fuentes-García SciProfiles Scilit