Kelly Coffey

If you are looking for a way to bring the Force to your holiday season, you're going to want to check out this interesting hack.

In case you aren't familiar, churros are fried pastry dough covered in delicious cinnamon sugar and are traditional in Spain and Portugal, where the snack was originated.

Disney Parks is filled with delicious and unique food and drink offerings. From iconic Mickey bars to buttery popcorn to, of course, the one and only Churro, Disney has so many choices.

Back in 1955, Disneyland opened up a unique Peter Pan themed restaurant. Beginning on August 29, 1955, the Chicken of the Sea Pirate Ship and Restaurant welcomed Guests to dine aboard a pirate ship!

Disney movie lovers everywhere have fun coming up with fan theories as they dive deeper into the stories we know and love.

Filled with grim grinning ghosts, singing busts, wall-to-wall creeps, hot and cold running chills, and of course, the Ghost Host, the Haunted Mansion , located at both Walt Disney World and Disneyland, draws in Guest after Guest as they visit the 999 happy haunts.

The androgen receptor (AR) is a key driver of prostate cancer (PCa) and, as such, current mainstay treatments target this molecule. However, resistance commonly arises to these therapies and, therefore, additional targets must be evaluated to improve patient outcomes. Consequently, alternative approaches for indirectly targeting the AR are sought. AR crosstalk with other signalling pathways, including several protein kinase signalling cascades, has been identified as a potential route to combat therapy resistance. The casein kinase 1 (CK1) family of protein kinases phosphorylate a multitude of substrates, allowing them to regulate a diverse range of pathways from the cell cycle to DNA damage repair. As well as its role in several signalling pathways that are de-regulated in PCa, mutational data suggest its potential to promote prostate carcinogenesis. CK1α is one isoform predicted to regulate AR activity via phosphorylation and has been implicated in the progression of several other cancer types. In this review, we explore how the normal biological function of CK1 is de-regulated in cancer, the impact on signalling pathways and how this contributes towards prostate tumourigenesis, with a particular focus on the CK1α isoform as a novel therapeutic target for PCa.

If you are the new proud owner of a puppy and you're struggling to find the perfect name for him or her, you are far from the only one. There are a ton of dog parents who want to take this as an opportunity to show their love for their favorite film or TV show character.

When it comes to the iconic fireworks at Magic Kingdom, there's one truth that every Disney fan knows: snagging the perfect spot on Main Street, U.S.A., is a coveted achievement.

From its humble beginnings in 1923 to becoming the global entertainment powerhouse it is today, Disney has a long history of shaping the imaginations of generations around the world.