Lindsey Pallares

The San Francisco 49ers are set to face the 7-3 Green Bay Packers on the road without their starting quarterback. QB1 Brock Purdy (right shoulder) was ruled out of the team's Week 12 contest after being a limited participant in practice on Wednesday and Thursday and sitting out of Friday's workout altogether. The 49ers third-year quarterback suffered his right shoulder injury in San Francisco's Week 11 matchup against the Seattle Seahawks.

The San Francisco 49ers returned home after a couple of tough road games to host the Chicago Bears (4-8). For a third-straight week, the team was without a couple of key starters in defensive lineman Nick Bosa (hip/oblique) and left tackle Trent Williams (ankle), and Sunday marked back-to-back games without starting left guard Aaron Banks (concussion). Despite missing important personnel, the red and gold took control of this game early and never surrendered the lead, routing the Chicago Bears 38-13.

Thursday night's primetime matchup could mark the return of a couple of big-time defensive players for the San Francisco 49ers. Defensive lineman Nick Bosa (hip/oblique) and linebacker Dre Greenlaw (Achilles) have been listed as questionable in the team's final injury report of the week. On Wednesday, Bosa was upgraded to a limited participant in the team's walkthrough activities for the first time since aggravating his hip/oblique injuries against the Seattle Seahawks in Week 11. Meanwhile, Greenlaw is in the third week of his practice window from the Reserver/Physically Unable to Perform list. While the 49ers have yet to decide if they will activate him to the 53-man roster, the option remains on the table as of Monday.

In Week 15, the red and gold have defensive lineman Nick Bosa and linebacker Dre Greenlaw active and ready for the team's second meeting with their NFC West rival, the Los Angeles Rams.

The San Francisco 49ers will have both defensive lineman Nick Bosa (hip/oblique) and linebacker Dre Greenlaw (Achilles/knee) on hand for their Week 16 matchup. Bosa was dealing with a hip/oblique injury that kept him out of practice for the majority of the week, but after rejoining the team on Friday, he was given the green light to play versus the Miami Dolphins. Meanwhile, Greenlaw emerged from his 2024 debut on "Thursday Night Football" with Achilles/knee soreness, but after three-straight practices of limited participation, he is good to go as well.

The San Francisco 49ers will head into a rematch of last season's NFC Championship Game versus the Detroit Lions with a reworked offensive line. Just two of the red and gold's Week 1 starters - right guard Dominick Puni and center Jake Brendel

The San Francisco 49ers will look to at least a couple newly signed and younger players to help carry the offensive line in Week 17. Injuries over the course of the second half of the season have resulted in left guard Aaron Banks (knee) and left tackles Trent Williams (ankle) and

The San Francisco 49ers concluded their 2024 season on the road against the Arizona Cardinals. Among the long list of of injured players not suiting up for the season finale was QB1 Brock Purdy, who suffered a right elbow contusion and nerve inflammation in the team's Week 17 "Monday Night Football" matchup. With Purdy out of the lineup, Joshua Dobbs led the 49ers offense in the last game of the year. Dobbs has history with Arizona - he spent the first portion of the 2023 season as the Cardinals starting quarterback while Kyler Murray recovered from an ACL injury. He finished the day connecting on 29-of-43 passes for 326 yards, two touchdown passes and two interceptions.

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