Lu Wang

(Bloomberg) -- The surge in Destiny XYZ, a newly launched fund whose shares have exploded some 500% since late March, is a “discovery process” as

The surge in Destiny XYZ, a newly launched fund whose shares have exploded some 500% since late March, is a “discovery process” as investors gauge the value of a vehicle offering easy access to some prestigious privately held technology firms.

Chromosomal instability is a prominent biological feature of myelodysplastic syndromes (MDS), with over 50% of patients with MDS harboring chromosomal

(Bloomberg) -- The meme-stock crowd wants a piece of the rarefied world of private assets, and — for now — there's big money to be made on Wall Street for anyone who can give it to them.

(Bloomberg) -- The meme-stock crowd wants a piece of the rarefied world of private assets, and — for now — there’s big money to be made on Wall Street for anyone who can give it to them.Most Read from BloombergChina Tells Iran Cooperation Will Last After Attack on IsraelBeyond the Ivies: Surprise Winners in the List of Colleges With the Highest ROIUS Two-Year Yield Eyes 5% Before Powell’s Remarks: Markets WrapIMF Steps Up Its Warning to US Over Spending and Ballooning DebtIran’s Conflict With Is

A new Wall Street clash has broken out between Cathie Wood’s ARK Investment Management and the firm behind a young fund targeting private assets that has taken the investing world by storm.

Exosomes are emerging mediators of cell-cell communication, which are secreted from cells and may be delivered into recipient cells in cell biological processes. Here, we examined microRNA (miRNA) expression in esophageal squamous cell carcinoma (ESCC) cells. We performed miRNA sequencing in exosomes and cells of KYSE150 and KYSE450 cell lines. Among these differentially expressed miRNAs, 20 of the miRNAs were detected in cells and exosomes. A heat map indicated that the level of miR-451a was higher in exosomes than in ESCC cells. Furthermore, miRNA pull-down assays and combined exosomes proteomic data showed that miR-451a interacts with YWHAE. Over-expression of YWHAE leads to miR-451a accumulation in the exosomes instead of the donor cells. We found that miR-451a was sorted into exosomes. However, the biological function of miR-451a remains unclear in ESCC. Here, Dual-luciferase reporter assay was conducted and it was proved that CAB39 is a target gene of miR-451a. Moreover, CAB39 is related to TGF-β1 from RNA-sequencing data of 155 paired of ESCC tissues and the matched tissues. Western Blot and qPCR revealed that CAB39 and TGF-β1 were positively correlated in ESCC. Over-expression of CAB39 were cocultured with PBMCs from the blood from healthy donors. Flow cytometry assays showed that apoptotic cells were significantly reduced after CAB39 over-expression and significantly increased after treated with TGF-β1 inhibitors. Thus, our data indicate that CAB39 weakens antitumor immunity through TGF-β1 in ESCC. In summary, YWHAE selectively sorted miR-451a into exosomes and it can weaken antitumor immunity promotes tumor progression through CAB39.

Abstract As sessile organisms, plants are increasingly vulnerable to environmental stresses because of global warming and climate change.

Gaoxiu Qiao Yijun Pan Chao Liang Lu Wang Jinghui Wang First published:

Zi-Qi Wang Tian-Rui Qu Zhi-Shuai Zhang Fan-Shu Zeng Hong-Jian Song