Lu Wang

As investors increasingly turn to artificial intelligence for help with everything from stock picking to risk management, JPMorgan Chase & Co. has

This Reprint presents a curated collection of ten original research and review articles published in the Special Issue Recent Advancement in Microwave Photonics of the journal Photonics. It provides an overview of recent theoretical advances and practical applications in microwave photonics, a field that combines microwave engineering and photonics to address key limitations of conventional electronic systems, including limited bandwidth, high transmission loss, and electromagnetic interference.The contributions within this Reprint span various dimensions, from fundamental photonic integrated components to advanced system-level implementations. At the device level, high-performance silicon nitride (SiN) bent waveguides with modified Hermite curves, high-power silicon-based spot-size converters, and ultra-compact multimode micro-racetrack resonators are explored. Design innovations using B-spline curves and inverse design methods are highlighted to improve couplers and filters. At the system level, this Reprint investigates high-sensitivity microwave phase noise analyzers, frequency-stabilized optoelectronic oscillators (OEOs), and the integration of microwave photonics in radar systems for improved resolution and precision.

Using detailed timestamp data for patient visits and laboratory test orders from the emergency department (ED) of a large, urban, teaching hospital in the United States, we examine the operational effectiveness of the full capacity protocol (FCP), a set of temporary hospital-wide guidelines that seek to alleviate crowding at the ED. We use an instrumented difference-in-differences approach and construct a comparable treatment group prior to the introduction of the FCP. Our results indicate that the FCP is effective in reducing the patient length of stay (LOS) when activated. Patients who arrived when the FCP was activated experienced an estimated reduction in LOS of 6.23%. This reduction was achieved through shorter waiting and after-treatment times. The reduction in after-treatment time helped expedite access to the treatment area for waiting patients, alleviating the bottleneck and improving the throughput, consistent with the theory of swift even flow and the theory of constraints. We also find an inverted-U-shaped relationship between boarding census and after-treatment time when the FCP was on, a pattern not observed under similar crowding levels when the FCP was not on.

Wall Street is racing to roll out complex investment products tied to SpaceX shares that aim to shield buyers from future losses amid a sharp selloff following its market debut.

José María Casanova Graphics Software Engineer Igalia

Introduction Recanalisation rates following standard intravenous thrombolysis (IVT) for acute ischaemic stroke due to medium or large vessel occlusion (MeVO/LVO) remain unsatisfactory, leading to poor clinical outcomes. Tenecteplase (TNK), a fibrin-specific thrombolytic agent, demonstrates potential advantages over alteplase, including higher recanalisation rates in LVO. Preliminary evidence suggests that a second dose of thrombolytic in patients with persistent vessel occlusion after initial IVT may be feasible and beneficial. This study aims to evaluate the efficacy and safety of a second intravenous dose of TNK administered to patients with acute anterior and posterior circulation MeVO/LVO who have not recanalised 1 hour after standard IVT.Methods and analysis RITIS-TNK2 is a prospective, randomised, open-label, blinded endpoint, multicentre, superiority trial. Eligible patients will be randomly assigned (1:1) to receive a second dose of TNK (0.25 mg/kg intravenously, capped at a maximum total dose of 16 mg) plus standard medical care or standard medical care alone. The primary efficacy outcome is the recanalisation rate of the occluded artery at 24 hours after randomisation. The primary safety outcome is symptomatic intracranial haemorrhage within 24 hours. Secondary outcomes include functional status at 90 days (modified Rankin Scale score). The expected recanalisation rate at 24 hours in the control group is estimated at 45%. We hypothesise rescue TNK will raise 24-hour recanalisation rate from 45% to 65%, representing an absolute 20 percentage-point improvement and a relative 44.4% increase. A maximum of 198 patients are required to test the superiority hypothesis with 80% power according to a two-sided 0.05 level of significance.Ethics and dissemination This study has been approved by the central Institutional Review Board (General Hospital of Northern Theater Command; IRB: Y (2025) 502). The study results will be disseminated through peer-reviewed journals and presentation at relevant national and international scientific conferences, regardless of the direction of the findings.Trial registration number [NCT07375966][1].[1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT07375966&atom=%2Fbmjopen%2F16%2F8%2Fe120918.atom

An exchange-traded fund strategy that delivers Treasury bill-like returns with lower taxes is getting a fresh boost as Wall Street firms bet the approach will survive rising scrutiny from the US Treasury.

An exchange-traded fund strategy that delivers Treasury bill-like returns with lower taxes is getting a fresh boost as Wall Street firms bet the approach will survive rising scrutiny from the US Treasury.

A long-standing question in atmospheric science concerns how, and to what extent, climate variabilities across different timescales interact to shape global weather and climate extremes. Here we address this issue through a quantitative framework that integrates both large-scale climate controls and upscale feedback processes. Coherent co-variability across multiple timescales appears throughout the global monsoon (GM) domain. Land precipitation on the interannual timescale exhibits a coherent in-phase relationship across all the sub-monsoon systems, largely governed by El Niño-Southern Oscillation (ENSO). Meanwhile, Madden-Julian Oscillation (MJO)-related precipitation accounts for about 30–65% of total intraseasonal precipitation variability across the sub-monsoon regions. Significant positive correlations are found between the interannual variability (IAV) and the intensity of the intraseasonal oscillation (ISO) and between the ISO and the intensity of synoptic-scale variability (SSV) across the entire GM domain, indicating a large-scale control of lower-frequency modes to higher-frequency variabilities. It is further demonstrated that higher-frequency variabilities (e.g., SSV and ISO) exert marked upscale feedback to lower-frequency modes through nonlinear rectification of condensational heating. About 90% of extreme precipitation days occur during the active phase of the ISO across the GM domain, laying a foundation for sub-seasonal prediction of weather and climate extremes weeks and even months ahead.

In this study, a nonlinear creep constitutive model for rock considering stress hardening-damage coupling is established.