Luis Miguel

Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos 47620, Mexico

Abstract Naïve pluripotency is sustained by a self-reinforcing gene regulatory network (GRN) comprising core and naïve pluripotency-specific

As the organizational environment becomes more volatile, uncertain, complex, and ambiguous, and the economy becomes increasingly knowledge-based, organizational knowledge management is key for companies' success. This is especially important as organizational ties are weaker and job-hopping becomes a more prevalent phenomenon. As human resource mobility increases, companies must ensure that knowledge remains within the company despite employee exit. In this context, the current study sought to understand how leaders' actions can facilitate employee knowledge sharing, focusing on paradoxical leadership. Besides examining the impact of paradoxical leadership on employees' propensity to adopt knowledge-sharing behaviors, this study also explored the effects of one potential intervening variable (i.e., promotive voice behavior) and one potential boundary condition (i.e., trust in the leader) on this relationship. A two-wave time-lagged correlational study was conducted with a sample of 154 workers from various sectors. The results of moderated mediation analysis suggest that paradoxical leaders indirectly promote greater knowledge-sharing among subordinates by fostering their promotive-voice behaviors, but only for those with high levels of trust in the leader. The implications of these findings for current organizational challenges regarding knowledge management are discussed.

EJNMMI Radiopharmacy and Chemistry , Sep 2024 Radiopharmaceuticals have been considered a special group of medicines in Europe since 1989.

Exposure to pesticides, poses a significant threat to male fertility by compromising crucial cells involved in spermatogenesis. Aminocarb, is a widely used carbamate insecticide, although its detrimental effects on the male reproductive system, especially on sustentacular Sertoli cells, pivotal for spermatogenesis, remains poorly understood. In this study, we investigated the effects of escalating concentrations of aminocarb on a mouse Sertoli cell line, TM4. Assessments included cytotoxic analysis, mitochondrial biogenesis and membrane potential, expression of apoptotic proteins, caspase-3 activity, and oxidative stress evaluation. Our findings revealed a dose-dependent reduction in the proliferation and viability of TM4 cells following exposure to increasing concentrations of aminocarb. Notably, exposure to 5 μM of aminocarb induced depolarization of mitochondria membrane potential, and a significant decrease in the ratio of phosphorylated eIF2α to total eIF2α, suggesting heightened endoplasmic reticulum stress via the activation of the eIF2α pathway. Moreover, the same aminocarb concentration was demonstrated to increase both caspase-3 protein levels and activity, indicating an apoptotic induction. Collectively, our results demonstrate that aminocarb serves as an apoptotic inducer for mouse sustentacular Sertoli cells in vitro, suggesting its potential to modulate independent pathways of the apoptotic cascade. These findings underscore the deleterious impact of aminocarb on spermatogenic performance and male fertility, highlighting the urgent need for further investigation into its mechanisms of action and mitigation strategies to safeguard male fertility.

Peruvian firm Diez Canseco Abogados has strengthened its litigation and arbitration offering by hiring an associate from Highly Recommended firm CMS Grau to lead its disputes area as partner.

Department of Obstetrics and Gynecology, Hospital da Luz Lisboa, Luz Saúde, 1500-650 Lisboa, Portugal

It is imperative to integrate advanced technologies and management practices to achieve operational excellence and sustainability in the contemporary manufacturing landscape, which is characterized by intense competitive pressures and stringent sustainability regulations. This systematic review of several databases from 1997 to 2024 was conducted in line with PRISMA guidelines to investigate how Industry 4.0 and Total Quality Management (TQM) integration can enhance sustainability performance in manufacturing organizations. Grounded within the dynamic capabilities framework, this research identifies the key drivers and barriers to adopting Industry 4.0 and examines their impact on the implementation of TQM. The findings reveal that technologies significantly enhance TQM by improving operational efficiency, reducing waste, and boosting product quality. However, barriers such as resource constraints, resistance to change, and data privacy concerns hinder this integration. This research suggests that dynamic capabilities—sensing, learning, coordinating, and integrating—are critical for successfully merging Industry 4.0 and TQM. This research enhances the academic dialogue on integrating Industry 4.0 and TQM by offering foundational insights into their theoretical and practical implications to achieve sustainability goals.

Mathematical Model to Study the Effect of Refuge on Cannibalism in Atractosteus tropicus

Laboratory for Process Engineering, Environment, Biotechnology and Energy (LEPABE), Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr.