Luis Miguel

It is imperative to integrate advanced technologies and management practices to achieve operational excellence and sustainability in the contemporary manufacturing landscape, which is characterized by intense competitive pressures and stringent sustainability regulations. This systematic review of several databases from 1997 to 2024 was conducted in line with PRISMA guidelines to investigate how Industry 4.0 and Total Quality Management (TQM) integration can enhance sustainability performance in manufacturing organizations. Grounded within the dynamic capabilities framework, this research identifies the key drivers and barriers to adopting Industry 4.0 and examines their impact on the implementation of TQM. The findings reveal that technologies significantly enhance TQM by improving operational efficiency, reducing waste, and boosting product quality. However, barriers such as resource constraints, resistance to change, and data privacy concerns hinder this integration. This research suggests that dynamic capabilities—sensing, learning, coordinating, and integrating—are critical for successfully merging Industry 4.0 and TQM. This research enhances the academic dialogue on integrating Industry 4.0 and TQM by offering foundational insights into their theoretical and practical implications to achieve sustainability goals.

Mathematical Model to Study the Effect of Refuge on Cannibalism in Atractosteus tropicus

Laboratory for Process Engineering, Environment, Biotechnology and Energy (LEPABE), Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr.

Specialization in Internal Medicine, Department of Health, Universidad Santiago de Cali, Santiago de Cali 760035, Colombia

Summary Epidemiologic and economic data regarding osteoporotic fractures in Mexico is scarce and mostly outdated.

Tick-borne diseases have emerged as a major global public health problem in recent decades. The increasing incidence and geographical dissemination of these diseases requires the implementation of robust surveillance systems to monitor their prevalence, distribution, and public health impact. It is therefore not unexpected that tick-borne pathogens coexist in the same vectors, but the interactions of these agents between vectors and vertebrate hosts, including humans, remain poorly understood. The impact of infection in humans extends to the diagnostic challenges that arise when the same symptomatology can be associated with any tick-borne pathogen, and therapeutic recommendations only focus on the major or best-known tick-borne diseases, ignoring other lesser-known or less prevalent infections. Both surveillance systems and the holistic diagnosis of tick-borne pathogens are necessary tools to address the emergence of vector-borne diseases. In this study, we will focus on the main tick-borne viral, bacterial, and parasitic diseases in Spain to reflect the need to establish syndromic diagnostics in samples from patients with a history of tick bites and symptomatology compatible with them. On the other hand, and highlighting this need, innovations in molecular techniques, syndromic surveillance, and surveillance programs for ticks and tick-borne pathogens with public health implications are expected to be developed.

Background: Injuries represent one of the most challenging scenarios for both athletes and teams. The aim of this systematic review was to examine the incidence and epidemiological data of injuries in female futsal players. Methods: A systematic search was conducted using PubMed, Scopus, SportDiscus, and Web of Science databases, and subsequently, nine studies were selected. Results: The most frequently damaged area is the ankle (28.15%), followed by the thigh (19.99%), knee (18.41%), and groin (17.26%), according to an analysis of nine studies, seven of which included data on professional futsal players and four of which included amateurs. Elite (28.62%) and amateur futsal players (27.06%) experience ankle injuries almost equally, whereas amateurs suffer thigh injuries (29.41%) far more often than elite athletes (13.71%). The most common injuries are strains (27.05%) and sprains (40.6%), with amateurs suffering from sprains more frequently (51%) than elite athletes (36.44%) and elite athletes suffering from strains more frequently (29.4%) than amateurs (20%). Conclusions: Ankle injuries are the most prevalent in female futsal players, with amateurs particularly prone to sprains. Based on these results, professionals in this field may identify injury patterns that could guide future prevention efforts specifically tailored to female futsal players.

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This is an uncorrected proof. Abstract Background

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an enzymopathy that affects approximately 500 million people worldwide. A great number of mutations in the G6PD gene have been described. However, three class A G6PD variants known as G6PD Tomah (C385R), G6PD Kangnam (C385G), and G6PD Madrid (C385W) have been reported to be clinically important due to their associations with severe clinical manifestations such as hemolytic anemia. Therefore, this work aimed to perform, for the first time, biochemical and functional characterizations of these variants. The G6PD variants were cloned and purified for this purpose, followed by analyses of their kinetic parameters and thermal stability, as well as in silico studies. The results showed that the mutations induced changes in the proteins. Regarding the kinetic parameters, it was observed that the three variants showed lower affinities for G6P and NADP+, as well as lower thermal stability compared to WT-G6PD. Molecular dynamics simulations showed that C385 mutations induced changes around neighboring amino acids. Metadynamics simulations showed that most remarkable changes account for the binding pocket volumes, particularly in the structural NADP+ binding site, with a concomitant loss of affinity for catalytic processes.