Manish Gupta

Silver, too, is on the rise, with Kishor Runwal from Anmol Jewellers highlighting a 25% increase compared to last year's festival season.

Silver, too, is on the rise, with Kishor Runwal from Anmol Jewellers highlighting a 25% increase compared to last year's festival season.

Objectives: Cervical cancer is the second most common malignancy among Indian women after breast cancer. This study was undertaken to determine the pattern of care, long-term survival outcomes, and prognostic factors for cervical cancer patients treated at a tertiary care cancer centre in North India.Methods: Ten-year data was retrieved for 435 stage I-IVA carcinoma cervix patients treated between 2009 and 2019. A sociodemographic profile of the patients, treatment methods, and conditions at follow-up were obtained.Statistical analysis: Data was analyzed using Stata 15.1 (StataCorp LLC, College Station, Texas, United States). Qualitative variables were shown as frequencies/percentages, and quantitative as means/standard deviations. Key endpoints were overall, disease-free, and locoregional survival. Kaplan-Meier curves represented survival. Cox regression models assessed parameter influence. Statistical significance was set at p < 0.05, with hazard ratios and 95% confidence intervals reported.Results: Fourteen (3.2%) patients underwent surgery; of the patients who underwent surgery, except two patients who underwent surgery alone, all patients received external beam radiotherapy (EBRT) followed by EBRT (26.4%) or brachytherapy boost (72.4%). Seventy-one per cent of patients received more than four cycles of concurrent chemotherapy. The median overall survival (OS) was 42.04 (0.25-171) months, and the median disease-free survival (DFS) was 32.85 months (1-171) months. The median overall survival was 58.76%, and the two-year and five-year overall survival percentages were 81.34% and 64.52%, respectively. The median time to locoregional relapse and distant metastasis was 35 (1-171) and 37.6 (1-171) months, respectively. Bilateral parametrial involvement was a predictor of poor OS (p = 0.039), DFS (p = 0.039), and locoregional failure-free survival (LFFS) (p = 0.020). Age less than 50 years was a predictor of worse DFS (p = 0.034) and LFFS (p = 0.005), while paraaortic nodal involvement was a predictor of worse DFS (p = 0.045). Grade III tumours neared numerical significance (p = 0.051) for worse distant metastases-free survival.Conclusion: Bilateral parametrial involvement was the most significant factor for OS, DFS, and LFFS. Paraaortic nodal involvement predicted poor DFS and young age was associated with poor DFS and LFFS.

Whether you're investing in a timeless piece or shopping for everyday adornments, knowing the purity of gold is essential for ensuring value and longevity.

Top/Best Gastroenterologist in Indirapuram/Ghaziabad, Delhi, Noida, Uttar Pradesh | Dr. Manish Kr Gupta is recognized for his work in chronic liver disease, pancreatitis, and IBD.

Due to globalization and technological advancements, competition and challenges among organizations have increased. To handle the current situation, organizations are in the process of implementing Industry 4.0. Industry 4.0 signifies the transition from embedded systems to cyber-physical systems in terms of technological advancement. With the advent of Industry 4.0, organizational processes are evolving in new ways from time to time to compete and increase profit in the market. Imprecise inventory and warehouse management lead to problems that incur costs and time. To tackle this, there is a need to re-engineer the process with the help of technological innovations. This study employs the Business Process Reengineering approach to redesign the process with Industry 4.0, aiming to gain a deeper understanding of the potential of re-engineered inventory and warehouse management. Incorporating Industry 4.0 technologies, such as the IoT, RFID, sensors, and AI, significantly improves inventory and warehouse management by enhancing accuracy, minimizing manual errors, and speeding up processing times in generating and approving purchase orders, quality checks, receiving and storing goods. The model enhances decision-making via IIP in vendor selection, preventing stockouts and overstocking, space optimization, pilferage, obsolescence, and follow-up, improving accuracy by combining predictive analytics and real-time data through sensors. Automation optimizes resource allocation, leading to cost savings, while blockchain and IoT ensure full traceability across the supply chain, promoting transparency and accountability among suppliers, warehouses, and departments. It offers practical insights for industries that modernize their supply chains, providing a scalable framework to encourage flexibility and adaptability in various contexts.

Abstract HIV-1 capsid proteins (CA) self-assemble into a fullerene-shaped capsid, enabling cellular transport and nuclear entry of the viral genome.

JAGDALPUR,INDIA: Chhattisgarh Chief Minister Vishnu Deo Sai highlighted Bastar’s transformation from a region plagued by Maoist violence to one illuminated by development initiatives.

Industry experts had warned that the previous figures were inflated due to double counting.

India's progress in ethanol adoption has been impressive, transforming from minimal usage to significant advancements today, said UNICA President Evandro Gussi at the Bharat Mobility Global Expo 2025.