Mark Hill

As Marvel brings back Robert Downey Jr. and Star Wars refuses to step beyond the long shadows of the Skywalker family, major franchises are more prone than ever to mistaking Easter eggs and callbacks for plotting. This is confusing to anyone outside the hardcore fandom; Ahsoka was rather dull to those who hadn’t watched the old cartoon preceding it, and the pauses Deadpool & Wolverine built in so theater-goers could gasp at the brief cameos of characters last seen decades ago feel silly when you’re watching at home.

“Jimmy's has long had some of the best seafood in town, but their new and improved LILF tank puts them in a whole new category,” said one reporter. “I recommend starting with the Caesar salad, having the medium-rare

Given that you can’t so much as change a lightsaber’s color without sparking canonical debates that rival the European wars of religion, it’s remarkable how willing Lucasfilm was to just toss ideas out there to see what would prove entertaining (and profitable) in the wake of the original trilogy’s unexpected success. While the Star Wars Holiday Special is the most infamous product of this period, a forgotten TV movie released less than a year after Return of the Jedi made it clear that no one knew quite what the future of Star Wars was, or if it even had one.

Players have been taunted and threatened for not playing well enough (or for playing well for the opposition). Raptor Chris Boucher was called a “slave” by a gambler, while former

A hell of a lot unfolds when you combine Paul Thomas Anderson, Thomas Pynchon, and Joaquin Phoenix.

Darren Fullerton, CEO of Suntory Beverage and Food Oceania, has announced he will retire in 2025, five years after joining the company.

Given that everything from major political scandals to minor cultural war skirmishes is declared Orwellian, it’s remarkable that we haven’t had a major adaptation of 1984 since its title year. Maybe that’s just because references to the work wildly outpace our collective understanding of it. But it also might also be tricky to top the John Hurt-led film. Celebrating its 40th anniversary today, it remains an effective telling that shows why Orwell’s story remains memorable, even as so many other dystopian sagas have fallen into the memory hole.

Purpose: Developing T cell or vaccine therapies for pancreatic ductal adenocarcinoma (PDAC) has been challenging due to a lack of knowledge regarding immunodominant, cancer-specific antigens, as a scarcity of genomic mutation-associated neoepitopes characterizes PDAC and there are limited availability of effective approaches to discover them. Experimental Design: We utilized an advanced mass spectrometry approach to compare the immunopeptidome of PDAC tissues and matched normal tissues from the same patients. Results: We identified HLA class I-binding variant peptides derived from canonical proteins, which had single amino-acid substitutions not attributed to genetic mutations or RNA editing. These amino-acid substitutions appeared to result from translational errors. The variant peptides were predominantly enriched in tumor tissues, with some peptides shared across patients. Importantly, several of these variant peptides were more immunogenic than their wild-type counterparts. Conclusions: The shared non-canonical neoepitopes identified in this study offer promising candidates for vaccine and T cell therapy development, potentially providing new avenues for immunotherapy in PDAC.

“If you simply obey the speed limit, you can plow right through the little tykes and be on your way with plenty of time to spare."

Boba Fett, one of the most iconic sci-fi characters ever created, only had four lines of dialogue across six-and-a-half minutes of screentime before he fell in a pit and perished.