Michael Berk

LEXINGTON, Ky. (LEX NEWS) — The 4th annual Jubilee Jobs Fair in central Kentucky is connecting job seekers with employers — including people with criminal backgrounds, substance abuse disorders, or other possible barriers to employment.

LEXINGTON, Ky. (LEX NEWS) — Sticker shock is taking on a whole new meaning at auto dealerships across America. According to Kelley Blue Book, the online service that values cars, the average price of a new vehicle has topped $49.000.

Abstract Background: Depression and anxiety are prevalent in working-aged adults.

Objectives To systematically evaluate the certainty of evidence for treatment strategies across age groups and mood phases in bipolar disorder, and develop an open access web platform to facilitate shared decision making.Design Living umbrella review, evaluation, analysis, and communication hub (U-REACH) project.Data sources PubMed, PsycInfo, and Cochrane library databases, from inception to 19 November 2024.Eligibility criteria for selecting studies Systematic reviews with network or pairwise meta-analyses of randomised controlled trials of pharmacological, nutraceutical, psychosocial, brain stimulation, or circadian rhythm based treatments, administered as monotherapy (without concurrent interventions), augmentation treatment (interventions added to an ongoing treatment regimen), or combination treatment (simultaneous initiation of two different interventions), examining any age group, bipolar disorder phase (ie, acute bipolar depression, mania or mixed episodes, or maintenance), treatment, control, or outcome.Results 77 studies met the inclusion criteria (21 network meta-analyses and 56 pairwise meta-analyses), including 116 unique pharmacological (n=74), brain stimulation (n=18), nutraceutical (n=13), psychosocial (n=8), and circadian rhythm based (n=3) treatments as monotherapy, augmentation, or combination therapy, along with five control interventions. These studies covered 133 unique outcomes (45 efficacy outcomes and 88 safety outcomes) resulting in 2510 meta-analyses with Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) ratings of the certainty of the evidence as high (n=236), moderate (n=827), low (n=986), and very low (n=461). A communication hub, the Evidence Based Interventions for Bipolar Disorder (EBI-BD) platform, was developed and the full results are freely available (), including the preference based tool (12 interventions and 17 safety outcomes). Interventions effective across outcomes varied by phases. For bipolar depression, effective interventions in adults were cariprazine, divalproex or valproate, fluoxetine, ketamine (augmentation), lamotrigine, lumateperone, lurasidone, olanzapine, olanzapine with fluoxetine, and quetiapine, whereas effective interventions in children and adolescents were lurasidone and olanzapine with fluoxetine. For mania episodes, effective interventions in adults were aripiprazole, asenapine, carbamazepine, cariprazine, divalproex or valproate, haloperidol, lithium, olanzapine, paliperidone, quetiapine (also augmentation), risperidone (also as augmentation), tamoxifen, and ziprasidone, whereas effective interventions in children and adolescents were aripiprazole, asenapine, olanzapine, quetiapine, and risperidone. For maintenance, interventions effective across outcomes in adults were aripiprazole (also the long acting injectable formulation), asenapine, divalproex or valproate, lithium, olanzapine, group psychoeducation (augmentation), quetiapine, and risperidone long acting injectable formulation. Interventions effective across phases were aripiprazole (also as augmentation and as a long acting injectable formulation), asenapine, cariprazine, cognitive behavioural therapy (augmentation), divalproex or valproate, lamotrigine, lithium, olanzapine (also as augmentation), paliperidone, quetiapine (also as augmentation), and risperidone (also as augmentation and the long acting injectable formulation) (adults). Treatment effects by neuroscience based nomenclature classes are also reported.Conclusions The EBI-BD tool can help clinicians make evidence based, personalised treatment decisions for bipolar disorder. This resource can inform clinical guidelines and provides a foundation for continuously improving bipolar disorder care as new evidence emerges.Trial registration Open Science FrameworkReaders’ note This is a living systematic review and may be updated in the next two years if additional evidence emerges.Data sharing: The complete results and data are freely accessible on the Evidence Based Interventions-Bipolar Disorder (EBI-BD) platform (). The analytic code is publicly available at .

The Ronald McDonald House of Lexington is usually the one helping families in need. Today, it was on the receiving end of some much-needed support.

The Kirwan-Blanding Hall dormitory has officially opened after a ribbon-cutting ceremony to commemorate the occasion.

The Ronald McDonald House of Lexington is usually the one helping families in need. Today, it was on the receiving end of some much-needed support.

LEXINGTON, Ky. (LEX NEWS) — Sydni Taylor was this close to leaving the house for the Lexington East End Day.

MADISON COUNTY, Ky. (LEX NEWS) — 13 years ago, Brittany Berry knew she had to do something. She was disgusted with what she had allowed her life to become.

LEXINGTON, Ky. (LEX NEWS) — From extreme weather conditions, to disease affecting the cattle and economic policy, there's growing concern and uncertainty among America's cattle farmers.