Michael J.

Background Few studies have described post-discharge morbidity of children with specific manifestations of severe malaria (SM) beyond severe malarial anaemia or cerebral malaria. Methods Children 6 months to 4 years of age admitted at Jinja and Mulago hospitals in Uganda, with one or more of the five most common forms of SM, cerebral malaria (n = 53), respiratory distress syndrome (n = 108), malaria with complicated seizures (n = 160), severe malarial anaemia (n = 155) or prostration (n = 75), were followed for 12 months after discharge, alongside asymptomatic community children (CC) (n = 120) of similar ages recruited from the households or neighbourhoods of the children with SM. Incidence and risk of hospitalizations, death or outpatient clinic visits were compared between children with SM and CC. Results 312/551 (56.6%) of children with SM had one or more post-discharge hospitalization over 12 months, compared to 37/120 (30.8%) of CC. Frequency of hospitalization was similar across all forms of SM. Compared to CC, children with SM had a significantly higher risk of all-cause hospitalization (adjusted hazard ratio (aHR) 1.91, 95% confidence interval (CI) 1.39–2.63, p  80% of hospitalizations were due to severe malaria. Studies of post-discharge malaria chemoprevention are urgently needed for children with SM, to determine if this treatment can reduce post-discharge morbidity.

The religious landscape of Aotearoa New Zealandis a dynamic and shifting field. One of the most riveting dimensions of religion is blooming via an indigenous Māori renaissance, which is displayed in a struggle over narratives, language, and tikanga (protocol) around sacred sites. In the digital age, social media platforms have become sites of negotiation, contestation, and the clarification of Māori religious authority in relation to sacred places. One of the hallmarks of digital culture is the flattening of traditional modes of hierarchical authority. In this article, we explore the discourse in an online news article's comment section debating tikanga around nudity on the summit of Taranaki Mountain, a place widely regarded as sacred to Māori. This project follows the work of Neumaier and Klinkhammer in tracing the contours of what we identify as a form of mediatised interreligious contact between settler secularity and Indigenous Māori. Using this frame, we argue that this case study affords a deeper understanding of Māori perspectives, settler appeals to secularity, and the digital environment shaping and forming these points of contact.

Rheumazentrum Ostschweiz, 9000 St. Gallen, Switzerland

Liquid biopsy assays are important to prognosticate outcomes of metastatic castration-resistant prostate cancer (mCRPC) patients treated with androgen receptor (AR) inhibitors. Here this group reports detecting circulating tumor DNA in limiting plasma cell-free DNA of mCRPC patients as prognostic marker of poor survival after AR treatment.

Breast cancer is the one of the most common cancers and causes a significant disease burden. Currently, postmastectomy radiotherapy (PMRT) is indicated for breast cancer patients with higher risk of recurrence, such as those with positive surgical margins or high-risk breast cancer (T3 with positive lymph nodes, ≥4 positive lymph nodes or T4 disease). Whether PMRT should be used in intermediate-risk breast cancer (T3 with no positive lymph nodes or T1-2 with 1-3 positive lymph nodes) is contentious. Rates of breast reconstruction postmastectomy are increasing in countries like Australia, and PMRT usage in such settings is another area of active research. Ongoing trials are also assessing the safety and efficacy of hypofractionated PMRT, a clinical scenario now widely accepted for early-stage breast cancer. This brief review is unique in that it aims to examine three current and controversial aspects of the PMRT field (PMRT in intermediate-risk breast cancer, PMRT in conjunction with breast reconstruction and its hypofractionation). To achieve this aim, we discuss available and emerging literature and guidelines to offer insights important to the PMRT field. Current literature suggests that PMRT could play a role in improving the overall survival rate and in reducing locoregional recurrence in intermediate-risk breast cancer. In terms of recommending a timing or type of breast reconstruction best suited to the setting of PMRT, we found that individual patient preferences and circumstances need to be considered alongside a multidisciplinary approach. Research into PMRT hypofractionation safety and efficacy is ongoing and its place remains to be elucidated.

Due to their immense economic and recreational value, the monitoring of Great Lakes water quality is of utmost importance to the region. Historically, this has taken place through a combination of ship-based sampling, buoy measurements, and physical models. However, these approaches have spatial and temporal deficiencies which can be improved upon through satellite remote sensing. This study details a new approach for using long time series of satellite remote sensing data to identify historical and near real-time anomalies across a range of data products. Anomalies are traditionally detected as deviations from historical climatologies, typically assuming that there are no long-term trends in the historical data. However, if present, such trends could result in misclassifying ordinary events as anomalous or missing actual anomalies. The new anomaly detection method explicitly accounts for long-term trends and seasonal variability by first decomposing a 10-plus year data record of satellite remote sensing-derived Great Lakes water quality parameters into seasonal, trend, and remainder components. Anomalies were identified as differences between the observed water quality parameter from the model-derived expected value. Normalizing the anomalies to the mean and standard deviation of the full model remainders, the relative anomaly product can be used to compare deviations across parameters and regions. This approach can also be used to forecast the model into the future, allowing for the identification of anomalies in near real time. Multiple case studies are detailed, including examples of a harmful algal bloom in Lake Erie, a sediment plume in Saginaw Bay (Lake Huron), and a phytoplankton bloom in Lake Superior. This new approach would be best suited for use in a water quality dashboard, allowing users (e.g., water quality managers, the research community, and the public) to observe historical and near real-time anomalies.

Abstract The environmental use of azole fungicides has led to selective sweeps across multiple loci in the Aspergillus fumigatus genome

Abstract Here we elucidate the intricate interplay between the nucleophilicity swing and pH swing mechanisms in aqueous quinone-mediated

Posada-Quintero et al. study the dynamics of the electrodermal activity and heart rate while breathing at elevated oxygen partial pressures in a hyperbaric environment. Electrodermal activitycan be used to predict the onset of central nervous system oxygen toxicity symptoms in divers resulting from prolonged exposure to a hyperbaric environment.

The 1995 Benguela Niño, the strongest in the past 40 years, was intensified by high freshwater discharge from the Congo River due to a major Indian Ocean Dipole in late 1994, according to analysis of oceanic, atmospheric and hydrological data.