Patrick A

Tonight at Arthur Ashe Stadium, a heated matchup between NJPW Strong Champion Eddie Kingston and ROH Heavyweight Champion Claudio Castagnoli [...]

The use of mass spectrometry imaging for crystallinity detection offers improved matrix selectivity and sensitivity over the techniques, such as X-ray microscopy and Raman spectrometry, that are traditionally used with this work. Crystallinity is observed in electrospray laser desorption ionization mass spectrometry imaging (ELDI-MSI) as a high-intensity agglomeration of the analyte in a spatially resolved image. As this is an indirect method of crystallinity detection, confirmation of this method’s ability to detect crystallization in amorphous formulations is needed by directly correlating observations of tablet crystallinity by ELDI-MSI to those of an established detection technique. Micro-computed tomography (micro-CT) has the necessary sensitivity for this investigation and is ideal for use in evaluating the correlation with crystallinity detection by ELDI-MSI. In this work, micro-CT followed by ELDI-MSI, in the same location on tablets of amorphous formulations of miconazole spiked with trace levels of crystalline miconazole, were analyzed. Crystals detected by ELDI-MSI as an agglomeration spatially matched with the detected crystals but were chemically unidentified by micro-CT. The results of this correlation study and a conclusion about the effectiveness of ELDI-MSI as a complimentary technique to indirectly detect crystallinity in enabling formations of an amorphous API are presented.

γδ T cells are unique T lymphocytes with cytotoxic functions, targeting infections and tumours. Here authors show that the target killing function of γδ T cells is tightly regulated at the level of the availability of lytic molecules granzyme B and perforin.

Featured below are complete WWE NXT No Mercy results from Saturday, September 30, 2023. The following report was written by Rajah report [...]

Featured below are complete WWE Monday Night Raw results from Monday, October 9, 2023 at the CHI Health Center in Omaha, NE. The following r [...]

Featured below are complete AEW Dynamite: Title Tuesday results from Tuesday, October 10, 2023. The following report was written by Matt Boo [...]

Featured below are complete WWE Friday Night SmackDown results from Friday, October 13, 2023. The following report was written by Rajah [...]

Triple H on the season premiere of WWE Smackdown gave appreciation and thanks to WWE Official Adam Pearce, naming him the new Monday Night R [...]

As was universally predicted, the Saturday, 3rd February 2024, by-elections saw Zanu-PF Parliamentary and Local Authority Candidates walloping Tshabangu's CCC Candidates, together with candidates secretly sponsored by Chamisa (done to test the waters), but masquerading as Independents.

Journal of Social, Behavioral, and Health Sciences , Sep 2024 Rwanda has made considerable progressive policy efforts to significantly reduce