Pravin Kumar

Hey there! Let's dive into the world of Testing Machine Learning (ML) Systems. It's a bit different...

AMSTERDAM: From once having just as many 'international quality' hotel rooms as Las Vegas, India's hospitality industry is now large enough to have many 'winners'.

Abstract Proteins possessing double active sites have the potential to revolutionise enzyme design strategies.

India has the second most confident travelers in the APAC region, closely behind Hong Kong. China comes in third followed by Singapore and Taiwan.

ICAR-Indian Institute of Maize Research, Ludhiana 141004, India ICAR-Indian Agricultural Research Institute Regional Station, Karnal 132001, India

Lucknow: UP DGP Prashant Kumar has said that contrary to the perception, UP Police is not a trigger-happy force and sweeping generalizations, often

Introduction: The vulva is the external genitalia in females. Vulvar carcinoma is a rare entity, with squamous cell carcinoma as the most common histology while basal cell carcinoma, extra-mammary Paget’s disease, and melanoma are still rarer subtypes. Treatment often comprises a multidisciplinary approach with surgery being the mainstay, followed by adjuvant therapy, depending upon pathological stage and other factors. Neoadjuvant treatment is considered in locally advanced cases where upfront surgery would not achieve adequate margin or organ preservation (urethra and anal canal). Due to the rarity of the disease and initial presentation at advanced stages in third-world countries, it is important to have strict treatment protocols with identifications of various prognostic factors and regular timely follow-up, which would, in turn, improve treatment outcomes. Here, we are presenting our institutional retrospective cohort spanning over eight years.Methods: This is a retrospective descriptive study done in the department of surgical oncology of a tertiary care cancer center in India from January 2016 to April 2024. A total of 21 patients with histologically proven diagnoses of vulvar cancer were included in the analysis. Stage of disease, treatment modalities used, and disease outcomes in terms of survival were tabulated. Statistical analysis was done using SPSS version 17 for Windows (SPSS Inc., Chicago, IL).Results: The estimated five-year overall survival was ≈71% using Kaplan-Meier analysis. On univariate analysis (testing other factors), using a log-rank test, neither stage nor nodal positivity were significant prognostic factors for overall survival. Given the small number of cases, multivariate analysis was not possible.Conclusion: In carcinoma of the vulva, treatment should be individualized with multidisciplinary cooperation. In many series, stage, nodal positivity, and extracapsular extension are found to be significant prognostic factors, though our results did not correspond with these data probably due to a small cohort. The paucity of data, especially from India and other developing countries, necessitates the need for more studies, preferably multicentric, keeping in mind the low prevalence of disease.

We study the constraints on primordial magnetic fields (PMFs) in light of the global 21-cm signal observed during the dark ages. Primordial magnetic fields can heat the intergalactic medium (IGM) via magnetohydrodynamic effects. We investigate the impact of magnetic heating on the dark ages global 21-cm signal and constrain the present-day strength of primordial magnetic fields and their spectral indices. Since there were no stars during the dark ages, measuring the global 21-cm signal can provide pristine cosmological information. However, detecting this signal using ground-based telescopes is challenging. Several lunar and space-based experiments, such as FARSIDE, DAPPER, and FarView, have been proposed to detect the signal in future. Our findings indicate that measuring the 21-cm global signal during the dark ages can provide stronger bounds compared to the existing constraints from Planck 2016. Specifically, the bounds are independent of astrophysical uncertainties and stronger for spectral indices. Additionally, we explore the dark-ages consistency ratio, which can identify any nonstandard heating of the IGM by measuring the 21-cm signal at only three different redshifts. This approach could complement future experiments aimed at detecting the dark ages global 21-cm signal.

May 1983. A little over a month before Kapil's Devils felled the mighty Windies to emerge the world champions, Patna was rocked by the mysterious

He not only captured the nuances of power dynamics in rural India, he made the audience experience the complexities of human relationships, challenging the formulaic escapism of Bollywood.