Rahul Gupta

Background: Foreign body (coins, magnets, button batteries, and metallic foreign bodies) ingestion is common and causes significant morbidity and mortality in children aged six months to three years. Endoscopic removal of swallowed foreign substances is widely accepted, but sedation and general anesthesia may be required to alleviate pain and anxiety during the procedure. Dexmedetomidine is used as a sedative, hypnotic, anxiolytic, and analgesic. In this study, we aimed to investigate and compare the efficacy between the intranasal (IN) and intravenous (IV) routes for the administration of dexmedetomidine as an adjunct to propofol for the removal of foreign bodies in the esophagus at the cricopharynx level in pediatric patients.Materials and method: This prospective, double-blinded, randomized study was conducted on 80 patients of either sex and American Society of Anaesthesiologists physical status (ASA PS) I and II aged one month to 12 years with a foreign body in the esophagus at the cricopharynx level undergoing endoscopic foreign body removal. Patients were randomly allocated into groups A and B, with 40 patients each. In the preoperative area group A, IN, 3 mcg/kg, was dripped equally in both nostrils (supine position). In Group B, IV, 3 mcg/kg, diluted in normal saline, was administered intravenously slowly over 10 minutes. The onset of sedation was assessed using the Ramsay Sedation Scale (RSS) every 10 minutes following dexmedetomidine administration, and when an RSS score of 3 or above was achieved, the patient was transferred to the operation theater. In the operation room, patients were induced with injection propofol in a dose of 2 mg/kg or until the loss of verbal response. Parent separation scale scoring was used to evaluate the child’s behavior on separation from parents as a tool to assess the anxiolytic property of dexmedetomidine. Perioperative pain using the Wong-Baker Faces pain rating scale, heart rate (HR), oxygen saturation (SpO2), ECG, and blood pressure (BP) were monitored before drug delivery till the end of the procedure. Statistical analysis was done using SPSS version 24.0 (IBM Corp., Armonk, NY).Results: The mean time (minutes) in shifting to operation theater (33.8 ± 5) was significantly higher in group A compared to group B (10.7 ± 2.1) (p = 0.001). The mean Ramsay Sedation Score was higher at 10 and 20 minutes in group B as compared to group A. Group B had significantly lower pain (2.2 ± 1.4) (p ≤ 0.001) at 10 minutes, while in group A, the pain score decreased slowly and took more time but remains lower (1.35 ± 0.94) for longer duration (120 minutes) in the postoperative period in comparison to Group B (1.94 ± 0.35) (p = 0.002). Group B had a sharp hemodynamic decrease, while group A had slow, persistent changes.Conclusion: IN administration of dexmedetomidine is a safer and more effective mode of sedation to remove a foreign body from the esophagus at the cricopharyngeal level in pediatric patients. It provides stable and sustained hemodynamic parameters and longer postoperative pain relief compared to IV dexmedetomidine.

Atomic superfluids formed using Bose-Einstein condensates (BECs) in a ring trap are currently investigated in the context of superfluid hydrodynamics, quantum sensing, and matter-wave interferometry. The characterization of the rotational properties of such superfluids is important, but can presently only be performed by using optical absorption imaging, which completely destroys the condensate. Recent studies have proposed coupling the ring BEC to optical cavity modes carrying orbital angular momentum to make minimally destructive measurements of the condensate rotation. The sensitivity of these proposals, however, is bounded below by the standard quantum limit set by the combination of laser shot noise and radiation pressure noise. In this work we provide a theoretical framework that exploits the fact that the interaction between the scattered modes of the condensate and the light reduces to effective optomechanical equations of motion. We present a detailed theoretical analysis to demonstrate that the use of squeezed light and backaction evasion techniques allows the angular momentum of the condensate to be sensed with noise well below the standard quantum limit. Our proposal is relevant to atomtronics, quantum sensing, and quantum information.

Abstract We quantify cellular- and circuit-resolution neural network dynamics following therapeutically relevant doses of the psychedelic psilocybin.

IntroductionDiabetic foot ulcers (DFUs) are a significant complication of diabetes mellitus, often leading to major lower extremity amputation. Identifying predictive factors for amputation can guide interventions to prevent this severe outcome. This study aimed to identify predictors of major lower extremity amputation in type 2 diabetic patients with DFUs.MethodologyA cross-sectional analytical study was conducted at the Department of General Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India, involving 101 patients with DFUs. The study assessed the association between various clinical and laboratory predictors and the necessity for major lower extremity amputation.ResultsSignificant predictors for amputation included Wagner's grade ≥ 5, absent peripheral pulsation, clinical evidence of infection, and elevated levels of erythrocyte sedimentation rate and C-reactive protein.ConclusionThis study highlights the importance of early identification of high-risk patients through detailed clinical assessment and laboratory investigations and underscores the need for aggressive management strategies targeting identified predictors to reduce the risk of major amputation among patients with DFUs.