Richard W

TCU Horned Frogs tight end Jared Wiley (19) runs on the field during an NCAA football game against SMU on Saturday, Sept. 23, 2023, in Fort Worth, Texas. (AP Photo/Richard

There are unpredictable disasters, like earthquakes, and predictable disasters, like deaths caused by a war. And there are predictable disasters, like a surge in crime stemming from abolishing bail, as the state of Illinois has just begun, that can be averted.

Policy-makers should promote genuine pluralism within American higher education rather than using heavy-handed regulations to impose uniformity.

Genome complexity is a distinguishing feature of advanced cancers in contrast to precancerous conditions. Here, by analysing chromosomal copy-number evolution in early cancers and precancerous lesions of the oesophagus, the authors reveal signatures of ongoing chromosomal instability and its role in promoting tumour progression.

Todd R. Overman and Richard W. Arnholt of Bass, Berry & Sims PLC discuss Commercial Solutions Openings, a contracting mechanism through the Department of Defense, which seeks innovative commercial technologies or services.

Filaments of the FtsZ protein can form chiral assemblies. Now, active matter tools link the microscopic structure of active filaments to the large-scale collective phase of these assemblies.

Phyllachora maydis is a fungal pathogen causing tar spot of corn (Zea mays L.), a new and emerging, yield-limiting disease in the United States. Since being first reported in Illinois and Indiana in 2015, P. maydis can now be found across much of the corn growing regions of the United States. Knowledge of the epidemiology of P. maydis is limited but could be useful in developing tar spot prediction tools. The research presented here aims to elucidate the environmental conditions necessary for the development of tar spot in the field and the creation of predictive models to anticipate future tar spot epidemics. Extended periods (30-day windowpanes) of moderate mean ambient temperature (18–23 °C) were most significant for explaining the development of tar spot. Shorter periods (14- to 21-day windowpanes) of moisture (relative humidity, dew point, number of hours with predicted leaf wetness) were negatively correlated with tar spot development. These weather variables were used to develop multiple logistic regression models, an ensembled model, and two machine learning models for the prediction of tar spot development. This work has improved the understanding of P. maydis epidemiology and provided the foundation for the development of a predictive tool for anticipating future tar spot epidemics.

Do all jobs have the same value? More people working should lead to higher real incomes, except when the jobs are destroying wealth.

Mutations in the FKBP14 gene encoding the endoplasmic reticulum resident collagen-related proline isomerase FK506 binding protein 22 kDa (FKBP22) result in kyphoscoliotic Ehlers–Danlos Syndrome (EDS), which is characterized by a broad phenotypic outcome. A plausible explanation for this outcome is that FKBP22 participates in the biosynthesis of subsets of collagen types: FKBP22 selectively binds to collagens III, IV, VI, and X, but not to collagens I, II, V, and XI. However, these binding mechanisms have never been explored, and they may underpin EDS subtype heterogeneity. Here, we used collagen Toolkit peptide libraries to investigate binding specificity. We observed that FKBP22 binding was distributed along the collagen helix. Further, it (1) was higher on collagen III than collagen II peptides and it (2) was correlated with a positive peptide charge. These findings begin to elucidate the mechanism by which FKBP22 interacts with collagen.

Abstract Foodcrusts have received relatively little attention in the burgeoning field of proteomic analysis of ancient cuisine.