Sandra Black

Four of Hollywood's biggest names are up for a coveted Oscar alongside their partners - how romantic!

Poor motor function, including gait dysfunction, is often observed in people with dementia. O'Keeffe ST Kazeem H Philpott RM

Since Hugh Grosvenor's engagement announcement in April, one question has been on everyone's mind- just who is the lucky girl who is marrying Britain's most eligible bachelor?

Olivia is a 30-year-old senior account manager who won the wedding lottery as she prepares to marry the Duke of Westminster.

Fifty participants diagnosed with MDD or persistent depressive disorder (PDD) will be recruited from a tertiary mood disorders clinic and undergo 1:1 randomization into either an experimental or control arm. Participants will be given either 25 mg psilocybin or 25 mg microcrystalline cellulose (MCC) placebo for the first treatment. Three weeks later, those in the control arm will transition to receiving 25 mg psilocybin. We will investigate whether treatments are associated with changes in arterial spin labelling and blood oxygenation level-dependent contrast neuroimaging assessments at acute and subacute timepoints. Primary outcomes include testing whether psilocybin demonstrates acute changes in (1) cerebral blood flow and (2) functional brain activity in networks associated with mood regulation and depression when compared to placebo, along with changes in MADRS score over time compared to placebo. Secondary outcomes include changes across complementary clinical psychiatric, cognitive, and functional scales from baseline to final follow-up. Serum peripheral neurotrophic and inflammatory biomarkers will be collected at baseline and follow-up to examine relationships with clinical response, and neuroimaging measures.

Scientific Reports , Article number: Cite this article Abstract Autism spectrum disorder (ASD) is diagnosed using comprehensive behavioral information.

Just like Christmas markets have become a staple of the festive holidays, what's Halloween without a day out pumpkin picking.

Visiting the pumpkin patch has become a must-do come Halloween time – so we've complied the best pumpkin patches in Leinster to help with your wholesome day out.

Just like Christmas markets have become a staple of the festive holidays, what's Halloween without a day out pumpkin picking.

With a fan club of admirers that includes Maura Higgins, the actor has been in a relationship for over two decades with his wife Amelia Warner.