Sean M

Pembrolizumab is a monoclonal antibody that targets the programmed cell death protein 1 (PD-1) receptor on T-cells, thereby enhancing the antitumor immune response. Pembrolizumab has been shown to improve survival in various cancers, but it can also cause immune-related adverse events (irAEs), which can affect any organ system. We report two cases of rare but serious irAEs caused by pembrolizumab: myasthenia gravis (MG) and peripheral neuropathy. Both patients presented with neuromuscular symptoms after receiving pembrolizumab for their advanced cancers. They were diagnosed with MG and peripheral neuropathy based on their clinical features, laboratory tests, and unremarkable imaging. Treatment involved discontinuing pembrolizumab and initiating immunosuppressive and supportive therapies. Both patients experienced improvement in their symptoms and quality of life once pembrolizumab was permanently discontinued and supportive therapies were in place. These cases highlight the importance of recognizing and managing rare irAEs of pembrolizumab, such as MG and peripheral neuropathy. Early diagnosis and treatment can improve outcomes and reduce morbidity. Furthermore, these cases emphasize the need for continued post-marketing surveillance to accurately assess the risk of less frequent adverse drug reactions seen in patients on pembrolizumab. Knowledge of these adverse reactions is important when discussing the pros and cons of this novel therapy with patients.

Players from Frontier and Hamburg head through the handshake line, after the Falcons defeated the Bulldogs, 3-0, on Sept. 8.

On August 23, 2023, the Securities and Exchange Commission (the SEC or the Commission) voted 3-2 to adopt a suite of new and amended rules (the Final…

Kawhi Leonard of the Los Angeles Clippers watches an NBA game from the team bench but new league rules on resting top stars could impact how he and other big-name

Here, the authors present a novel approach for inferring in vivo growth phases of human gut bacteria from metagenomic time series data. These inferences can be used to better-constrain community scale metabolic modeling in the gut.

Ulcerative colitis is a chronic inflammatory bowel disease that results in continuous colon inflammation. It is uncommonly diagnosed during pregnancy, and if quiescent before pregnancy, becomes active very rarely. Current literature has found that amelioration of the disease can be common during the second and third trimesters. However, if ulcerative colitis is active, it has the potential to result in premature delivery and low birth weight. This case focuses on a rare presentation of primary ulcerative colitis diagnosed in a 22-year-old multiparous patient to highlight the importance of a comprehensive differential diagnosis in pregnant patients with seemingly benign symptomatology.

As vessels become more advanced and complex, fleet owners and operators are turning to cutting-edge software solutions to maximize efficiency and perf...

As researchers, developers, policymakers and others grapple with navigating socially beneficial advanced technology transitions — especially those associated with artificial intelligence, DNA-based technologies, and quantum technologies — there are valuable lessons to be drawn from nanotechnology. These lessons underscore an urgent need to foster collaboration, engagement and partnerships across disciplines and sectors, together with bringing together people, communities, and organizations with diverse expertise, as they work together to realize the long-term benefits of transformative technologies.

The Shapiro administration recently released its Interim Final Environmental Justice Policy (Interim Final Policy) along with a link to the latest Environmental Justice Mapping and Screening Tool (PennEnviroScreen). The policy took effect on Sept. 16, when official notice of the interim final rulemaking was published in the Pennsylvania Bulletin.

Gray wolf hunting and feeding priorities shift throughout the breeding season in accordance with prey availability.