Srinivas Reddy

Lucknow: Passengrs of the Sabarmati Express train had a providential escape in the early hours of Saturday as 20 coaches of the train derailed near Govindpuri station in Kanpur, authorities said. None was injured. North Central Railway (NCR) senior public relations officer Shashikant Tripathi told PTI that the accident occurred at 2.30 am. He said […]

The recent synchronised elephant census data by Tamil Nadu forest department not only shows a rise in elephant numbers in state but also indicates

Hyderabad: BRS working president KT Rama Rao hit out the State government for its inefficiency in handling of tensions in Jainoor mandal of Kumrambhim Asifabad district, following an attempted rape of a tribal woman. The incident led to widespread violence, resulting in significant property destruction. In a statement, Rama Rao condemned the State government's decision to […]

BackgroundMicrotubule-associated protein light chains (LC) 3A and 3B are the structural proteins of the autophagosomal membrane widely used as endogenous autophagy markers. LC3A and LC3B autophagosomes reportedly have a distinct subcellular localization yet their role in the transition from premalignant to malignant phase remains unclear. This exploratory study aimed to investigate the expression of autophagy-related proteins LC3A and LC3B in oral premalignant lesions (OPL) and oral squamous cell carcinoma (OSCC) cases.MethodologyA cross-sectional study was conducted on 100 OPL and 39 OSCC samples. OPL samples comprised both dysplastic and non-dysplastic lesions. The expression of LC3A and LC3B markers was evaluated in the study samples using immunohistochemistry and associated with dysplasia in OPL and with invasive OSCC versus OPL. Fisher’s exact test was used for statistical analysis.ResultsThere was a higher ratio of LC3A positivity in non-dysplastic OPL (31/38) compared to dysplastic premalignant lesions (36/62, p=0.017). There was a higher ratio of LC3B positivity in dysplastic OPL (16/62) compared to non-dysplastic lesions (4/38) with a trend towards statistical significance (p=0.075). There was no statistical difference in the ratio of LC3A positivity between OSCC (23/39) and premalignant (67/100) lesions, while the ratio of LC3B marker positivity was higher in OSCC cases (18/39) relative to premalignant lesions (20/100, p=0.003).ConclusionAutophagy-related proteins LC3A and LC3B may have different roles to play in a disease context manner. LC3A is likely to be negatively associated with dysplasia in OPL while LC3B expression is positively associated with carcinogenesis of OSCC, possibly including dysplasia.

As World Suicide Prevention Day is observed today, let us realise suicide is not a failure, but a public health issue that requires understanding, support, and action. Through collective efforts to promote education, compassion, and open conversations, we can create a world where fewer lives are lost to suicide

Department of Chemistry, Norwegian University of Science and Technology (NTNU), N-7491 Trondheim, Norway

In 1816, FW Ellis put forth the ‘Dravidian Proof', which showed that the South Indian languages of Tamil, Telugu, Kannada and Malayalam were related to each oth

Highlights Nizamabad: Illegal sand mining and transportations is going on under the supervision of the ruling as well as the Opposition parties' leaders at...

A policeman stopped a school bus after finding it swerving. On checking, the driver was found to be drunk. The bus was seized and the children sent home in another bus in Kalyan of Thane.

The classics are more important now than ever before because they foster cultural dialogue and remind us of our common humanity.