Sue Smith is a writer based in Telford, Ketley, focusing on local news and events in the United Kingdom. She writes for publications such as the Shropshire Star, Daily Mirror, and has also been featured in the Express & Star. Sue's articles cover a range of topics including community events, human interest stories, and sports.
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Shrewsbury, United Kingdom (Local)
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Sue's focus is primarily on local events and human interest stories, with a significant emphasis on family & relationships as well as sports. To engage Sue effectively, consider providing heartwarming or inspirational local stories from Telford and Ketley that revolve around community events, personal achievements, or uplifting tales of enduring love and commitment.
Additionally, given the coverage attributes related to government announcements and profile features, pitches could also involve unique profiles of individuals within the local community who have compelling stories or have made noteworthy contributions.
As Sue shows an interest in sports-related topics such as England icon Alessia Russo's performance analysis and Lionesses' matches against Spain, she might appreciate insightful commentary from experts about these subjects.
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By: Bo Wen, Eric J. Jaehnig, Sue Smith, Sara R. Savage, Paul W. Shafer, Lauren K., Xinpei Yi, Yongchao Dou, Hongwei Zhao, Zhiao Shi, Daming Gao, Valentina Hoyos, Yuxing Liao, Qiang Gao, Tobie D. Lee, Zile Fu
Highlights • Integrating tumor proteogenomics with cell line data reveals pan-cancer druggable targets •
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We designed a simulation program that mimics the CRISPR-Cas9 editing on evolving barcode and double strand break repair procedure along with cell divisions. Emerging barcode mutations tend to build upon previously existing mutations, occurring sequentially with each generation. This process results in a unique mutation profile in each cell. We sample the barcodes in leaf cells and reconstruct the lineage, comparing it to the original lineage tree to test algorithm accuracy under different parameter settings. Our computational simulations validate the reasonable assumptions deduced from experimental observations, emphasizing that factors such as sampling size, barcode length, multiple barcodes, indel probabilities, and Cas9 activity are critical for accurate and successful lineage tracing. Among the many factors we found that sampling size and indel probabilities are two major ones that affect lineage tracing accuracy. Large segment deletions in early generations could greatly impact lineage accuracy. These simulation results offer insightful recommendations for enhancing the design and analysis of Cas9-mediated molecular barcodes in actual experiments.
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By: Sue Smith, Dan L. Duncan, Morgan Welch Ibc
Abstract Solid tumours induce systemic immunosuppression that involves myeloid and T cells. B cell-related mechanisms remain relatively understudied.
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By: Sue Smith, Jason Karch, Dan L. Duncan, Natee Kongchan, Shebna Massey, Joel R. Neilson, Marrs McLean, Yang Gao, Emuejevoke Olokpa, Xiang Zhang, Anna Malovannaya, Chonghui Cheng, Arindam Chaudhury
Shebna Massey ∙ Natee Kongchan ∙ Yang Gao ∙ … ∙ Chonghui Cheng ∙ Xiang Zhang ∙ Joel R. Neilson
By: Yiwen Chen, Meng C. Wang, Yao Ding, George Miles, Anthony M. Mustoe, Hhmi Janelia, Fanglue Peng, Sue Smith, Lacey E. Dobrolecki, Weiyi Peng, Qianzi Tang, Liting Zheng, Zhibin Zhang, Thomas F. Westbrook, Ralf Bernd Nehring, Weijie Zhang
Longyong Xu ∙ Fanglue Peng ∙ Qin Luo ∙ … ∙ Mothaffar F. Rimawi ∙ Jeffrey M. Rosen ∙ Xi Chen
By: Sue Smith
Abstract Background Genome-wide association studies (GWAS) have identified more than 200 breast cancer risk-associated genetic
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