Venkata Krishna

Aaron Finch reckons he is yet to recover from a neck injury. Pat Cummins, who has captained just two ODIs this year, brought him on only in the 18th over, well after Indians settled down.

Around 60 journalists have got accreditation, but still can't enter India to cover tournament

Former skipper's local knowledge and IPL stint may finally help Black Caps to go all the way on the biggest stage.

His pace through the air, yorker, bouncer and aggression make him an indomitable proposition.

Be it IPL, CPL or BBL, these players are much sought after, which makes them experienced and capable to deal with a variety of situations

The three phases of New Zealand's batting that set up their big win in Chennai against Afghanistan.

Kane-less NZ endure a few anxious moments before running past England-slayers for 149-run win

Left-arm spinner's reliability and economy is a key component of potent Kiwi attack, that is one of the more rounded in the competition

The primary cause of atherosclerotic cardiovascular disease (ASCVD) is elevated levels of low-density lipoprotein cholesterol (LDL-C). Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a crucial role in this process by binding to the LDL receptor (LDL-R) domain, leading to reduced influx of LDL-C and decreased LDL-R cell surface presentation on hepatocytes, resulting higher circulating levels of LDL-C. As a consequence, PCSK9 has been identified as a crucial target for drug development against dyslipidemia and hypercholesterolemia, aiming to lower plasma LDL-C levels. This research endeavors to identify promising inhibitory candidates that target the allosteric site of PCSK9 through an in silico approach. To start with, the FDA-approved Drug Library from Selleckchem was selected and virtually screened by docking studies using Glide extra-precision (XP) docking mode and Smina software (Version 1.1.2). Subsequently, rescoring of 100 drug compounds showing good average docking scores were performed using Gnina software (Version 1.0) to generate CNN Score and CNN binding affinity. Among the drug compounds, amikacin, bestatin, and natamycin were found to exhibit higher docking scores and CNN affinities against the PCSK9 enzyme. Molecular dynamics simulations further confirmed that these drug molecules established the stable protein–ligand complexes when compared to the apo structure of PCSK9 and the complex with the co-crystallized ligand structure. Moreover, the MM-GBSA calculations revealed binding free energy values ranging from −84.22 to −76.39 kcal/mol, which were found comparable to those obtained for the co-crystallized ligand structure. In conclusion, these identified drug molecules have the potential to serve as inhibitors PCSK9 enzyme and these finding could pave the way for the development of new PCSK9 inhibitory drugs in future in vitro research.

Topological antiferromagnetic spin textures, including merons, antimerons, and bimerons, are demonstrated in synthetic antiferromagnets by three-dimensional vector imaging of the Néel order parameter and investigated by micromagnetic analysis.