William Yang

Japan and China are seeking to improve relations ahead of U.S. President-elect Donald Trump's return to the White House, but analysts say Beijing's

Print Days after unveiling the latest breakthroughs in its military modernization, the Chinese navy has set afloat a new amphibious assault

Praised in China for normalizing relations between Washington and Beijing, Carter’s decision to sever official ties with Taiwan has been a target of criticism

Taiwan's President Lai Ching-te reiterated his administration's willingness to welcome equal and dignified exchanges with China but said Beijing remains the obstacle for both sides to resume regular exchanges.

Huntington's disease (HD), a neurodegenerative disease, affects approximately 30,000 people in the United States, with 200,000 more at risk. Mitochondrial dysfunction caused by mutant huntingtin (mHTT) drives early HD pathophysiology. mHTT binds the translocase of mitochondrial inner membrane (TIM23) complex, inhibiting mitochondrial protein import and altering the mitochondrial proteome. The HTT N-terminal 17-amino acids sequence (N17) acts as a regulatory domain in HD pathogenesis; phosphomimetic modification of serine 13 and 16 of the N17 domain impacts subcellular localization, degradation, and ameliorates toxicity in mouse and cell models of HD. Using cellular and mouse (either sex) HD models, we investigated the mechanisms by which HTT phosphorylation affects intracellular localization. We demonstrate that introducing phosphomimetic mutations within the mHTT fragment N17 domain decreased TIM23 binding affinity and reduced inhibition of mHTT-mediated mitochondrial protein import. BACHD-SD mice expressing full-length mHTT harboring the same two N17 phosphomimetic mutations have an ameliorated HD-like phenotype as compared to mice expressing mHTT. Consistent with reduced toxicity in vivo, we found that the amount of full-length mHTT in brain mitochondria of BACHD-SD transgenic mice is less when the mHTT has two phosphomimetic mutations. To complement the relevance of the phosphomimic HTT findings, endogenous N17 phospho mHTT is less likely to translocate to the mitochondria compared to non-phosphorylated mHTT. We demonstrate that phosphorylation of mHTT at serines 13 and 16 is critical for negatively regulating mHTT mitochondrial targeting and that reducing mHTT mitochondrial localization and binding to TIM23 results in amelioration of mHTT-induced mitochondrial and neuronal toxicity.

Washington — A major railway project connecting China and Central Asia is set to begin construction in July, after over two decades of negotiation.

Print As TikTok's Sunday deadline to divest or face a U.S. ban approaches, hundreds of American users of the popular social media video app

TAIPEI, TAIWAN — China initiated a new round of diplomatic outreach to Japan and the European Union this week as Washington prepares for President-elect Donald Trump's inauguration.

Analysts say that while Beijing seeks more engagement with the Trump administration, the new US government’s China policy remains unclear

TAIPEI, TAIWAN — China is bracing for potential tariffs after U.S. President Donald Trump threatened to slap a 10% duty on Chinese imports as early as Feb. 1.